Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with GJB2 Gene Mutations

Xingang Zhang; Zhaoxin Ma; Jishan Zheng; Huiqing Xu; Jiewen Pan; Lanqiu Lv

doi:10.12659/MSM.938165

03 January 2023: Clinical Research

Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with Gene Mutations

Xingang Zhang ^1ABE , Zhaoxin Ma ^2DF , Jishan Zheng ^3CEF , Huiqing Xu ^3BC , Jiewen Pan ^4EF , Lanqiu Lv ^5G*

DOI: 10.12659/MSM.938165

Med Sci Monit 2023; 29:e938165

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Table 3 Results of the t test performed to examine differences in expression of inflammatory markers between genders and the severity of hearing loss.

Sample	Parameter	T	dof	Alternative	p-val	CI 95%	Cohen-d	BF10	Power	Significant
Cohort 1	A1	2.26	11.88	Two-sided	0.04	[0.04, 2.54]	1.03	2.18	0.77	Yes
	B1	2.71	11.57	Two-sided	0.02	[0.44, 4.09]	1.25	4.70	0.90	Yes
	C1	−0.89	27.61	Two-sided	0.38	[−112.59, 44.26]	0.28	0.468	0.12	No
	D1	0.89	19.07	Two-sided	0.38	[−72.32, 180.02]	0.35	0.468	0.15	No
	E1	0.30	22.36	Two-sided	0.77	[−3.77, 5.04]	0.11	0.359	0.06	No
	F1	−0.63	18.92	Two-sided	0.54	[−11.3, 6.09]	0.18	0.403	0.08	No
	G1	0.56	14.84	Two-sided	0.59	[−5.39, 9.2]	0.24	0.39	0.09	No
Cohort 2	A2	−1.74	17.51	Two-sided	0.10	[−0.91, 0.09]	0.66	1.061	0.41	No
	B2	0.54	25.84	Two-sided	0.59	[−0.57, 0.98]	0.20	0.389	0.08	No
	C2	−0.32	26.99	Two-sided	0.75	[−2.1, 1.54]	0.12	0.36	0.06	No
	D2	−2.68	16.02	Two-sided	0.02	[−3.82, −0.45]	1.02	4.34	0.76	Yes
	E2	−0.91	20.27	Two-sided	0.38	[−6.72, 2.65]	0.34	0.48	0.14	No
	F2	−0.86	25.18	Two-sided	0.40	[−1.01, 0.42]	0.32	0.461	0.13	No
	G2	−1.36	22.77	Two-sided	0.19	[−1.11, 0.23]	0.51	0.693	0.26	No
Cohort 3	A3	0.79	24.79	Two-sided	0.44	[−0.61, 1.37]	0.30	0.442	0.12	No
	B3	−0.26	25.06	Two-sided	0.80	[−0.74, 0.58]	0.09	0.36	0.06	No
	C3	1.55	15.96	Two-sided	0.14	[−0.66, 4.24]	0.62	0.84	0.36	No
	D3	−0.81	25.65	Two-sided	0.43	[−2.44, 1.06]	0.29	0.448	0.12	No
	E3	0.21	22.45	Two-sided	0.84	[−1.27, 1.55]	0.08	0.356	0.05	No
	F3	1.23	25.38	Two-sided	0.23	[−0.52, 2.05]	0.46	0.616	0.22	No
	G3	1.26	12.15	Two-sided	0.23	[−4.68, 17.47]	0.52	0.629	0.27	No
A – IL-2; B – IL-4; C – IL-6; D – IL-10; E – IL-17A; F – α-TNF; G – γ-IFN.

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Analysis of Serum Inflammatory Markers in Infants Under 6 Months of Age with Non-Syndromic Moderate and Severe Hearing Loss Associated with Gene Mutations

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