Narrative Review of Noninvasive Brain Stimulation in Stroke Rehabilitation

02 December 2022: Review Articles

Qian-ru Shen ^1AEF* , Meng-ting Hu ^1EF* , Wei Feng ^1A , Kun-Peng Li ^1AEFG** , Wu Wang ^2AG*

DOI: 10.12659/MSM.938298

Med Sci Monit 2022; 28:e938298

Table 3 Summary of clinical studies on post-stroke patients using tACS.

Study	No.	Targeted lesion	Study design	Frequency	Peak current intensity	Location	Schedule	Follow-up	Outcomes
Gall et al, 2015 []⁶⁸	20 (20)	Unilateral occipital stroke	RCT	30 Hz	1.5 mA	Frontal pole midline point	20 min daily for 10 days	2 months	Visual field change positively
Wu et al, 2016 []⁶⁶	60 (30)	Subacute stroke	RCT	20 Hz	400 μA	bilateral mastoids	30 min daily for 3 weeks	N/A	NIHSS and the TCD parameters (MFV, PI) in MCAs, ACAs, and PCAs positive
Räty et al, 2021 []⁶⁷	9 (9)	Hemianopia after chronic stroke	RCT	5–15 Hz	1.5 mA	Bilateral frontal pole	30 min during days 1–5 and 40 min during days 6–10	2 months	No difference in the median detection accuracy
NIHSS – NIH Stroke Scale; TCD – Transcranial Doppler; MCA – middle cerebral artery; ACA – anterior cerebral artery; PCA – posterior cerebral artery; MFV – mean flow velocity; PI – pulsatility index.