09 December 2022 : Clinical Research
Neuropsychological Features in Patients with General Paresis of the Insane at an Early Stage
Jun-Hua Gao12345ABE, Du-Yu Ding5BC, Yan-Yun Qi5AB, Yu-Ming Huang5AE, Jing-Lin Zhang5ADF, Wei Zhang1234ACEG*DOI: 10.12659/MSM.938316
Med Sci Monit 2022; 28:e938316
Table 2 Neuropsychological assessments of asymptomatic neurosyphilis (ANS), neurosyphilis-mild cognitive impairment (MCI), and neurosyphilis-dementia groups.
| ANS | Neurosyphilis-MCI | Neurosyphilis-dementia | F/H value | P value | |
|---|---|---|---|---|---|
| Overall cognition | |||||
| MMSE | 30.0 (28.75, 30.0) | 26.3±2.5* | 19.1±3.1** | 37.9 | <0.001 |
| MoCA | 26.0 (25.0, 29.0) | 20.6±3.5* | 13.1±3.9** | 40.07 | <0.001 |
| Memory function | |||||
| AVLT1R,2R,3R-immediate recall | 18.7±4.0 | 12.0 (11.0, 16.0)* | 6.2±4.3** | 30.42 | <0.001 |
| AVLT4R-short delay recall | 6.1±2.0 | 2.0 (0.0, 4.0)* | 0.0 (0.0, 0.5) | 29.309 | <0.001 |
| AVLT5R-long delay recall | 6.3±2.2 | 2.3±1.9* | 0.0 (0.0, 0.5) | 30.973 | <0.001 |
| AVLT6R-cue recall | 6.7±2.6 | 2.1±1.8* | 0.0 (0.0, 0.5) | 31.395 | <0.001 |
| RCFT delay recall | 14.3±7.5 | 2.0 (0.0, 6.0)* | 0.0 (0.0, 1.0) | 32.706 | <0.001 |
| Language | |||||
| BNT | 26.5 (24.75, 28.0) | 22.1±4.0* | 19.1±4.8 | 20.502 | <0.001 |
| VFT-animal | 24.1±7.3 | 16.5±5.8* | 10.9±5.3** | 18.626 | <0.001 |
| VFT-furniture | 23.1±8.1 | 14.2±4.9* | 8.3±4.8** | 23.941 | <0.001 |
| VFT-animal furniture alternation | 19.1±5.7 | 13.1±5.5* | 6.1±5.4** | 22.265 | <0.001 |
| Visuospatial ability | |||||
| RCFT-figure copying | 34.0 (28.75, 36.0) | 26.0 (14.0, 34.0)* | 9.5 (4.75, 26.25) | 21.562 | <0.001 |
| Attention | |||||
| TMT-A time (s) | 44.3±13.6 | 61.0 (55.0, 75.0) | 77.5 (64.75, 103.25)** | 26.817 | <0.001 |
| TMT-A accuracy (n) | 25.0 (25.0, 25.0) | 25.0 (23.0, 25.0) | 22.0 (20.0, 24.25)** | 20.869 | <0.001 |
| SDMT | 10.7±6.8 | 2.0 (0.0, 7.0)* | 0.0 (0.0, 1.25) | 24.705 | <0.001 |
| Executive function | |||||
| TMT-B time(s) | 108.8±27.1 | 147.2±41.4* | 217.5 (165.75, 240.0)** | 23.974 | <0.001 |
| TMT-B accuracy(n) | 25.0 (25.0, 25.0) | 25.0 (19.0, 25.0) | 12.5 (2.0, 25.0)** | 17.259 | <0.001 |
| SCWT-A time(s) | 24.6±4.6 | 33.0 (28.0, 39.0) | 54.3±25.8** | 19.892 | <0.001 |
| SCWT-A accuracy(n) | 50.0 (50.0, 50.0) | 50.0 (50.0, 50.0) | 49.5 (48.75, 50.0) | 11.364 | 0.003 |
| SCWT-B time(s) | 34.0 (30.0, 43.75) | 57.0 (42.0, 70.0) | 89.9±37.3** | 27.787 | <0.001 |
| SCWT-B accuracy(n) | 50.0 (50.0, 50.0) | 50.0 (49.0, 50.0) | 48.5 (41.75, 50.0) | 17.459 | <0.001 |
| SCWT-C time(s) | 86.2±30.9 | 115.0±46.6 | 178.4±88.2** | 10.502 | <0.001 |
| SCWT-C accuracy(n) | 55.0 (54.0, 55.0) | 51.0 (39.0, 55.0)* | 35.4±14.3 | 20.893 | <0.001 |
| ANS – asymptomatic neurosyphilis; MCI – mild cognitive impairment. * p ** p | |||||