16 January 2023>: Clinical Research
Usefulness of Detecting Brain-Derived Neurotrophic Factor in Intervertebral Disc Degeneration of the Lumbosacral Spine
Rafał Staszkiewicz 12ABDEF* , Dorian Gładysz 12ABDEF , Marcin Gralewski 12DEF , Kamil Bryś 2EF , Michał Garczarek 1EF , Marcin Gadzieliński 1EF , Wiesław Marcol 34E , Dawid Sobański 25B , Beniamin Oskar Grabarek 12ACDEFDOI: 10.12659/MSM.938663
Med Sci Monit 2023; 29:e938663
Table 5 Number of BDNF-positive fibers/1 mm2 and their concentrations according to the Pfirrmann scale obtained by immunofluorescence staining.
Degree of radiological degeneration | Number of BDNF-positive nerve fibers/1 mm2 | p-value | Concentration of BDNF [pg/mg] | p-value | ||
---|---|---|---|---|---|---|
Mean±SD | 95% CI | Mean±SD | 95 %CI | |||
2 | 16.44±39.07 | 4.27, 28.61 | 0.735 | 17.73±19.58 | 7.48, 28.34 | 0.989 |
3 | 15.32±29.00 | 0, 30.77 | 19.91±17.27 | 1.79, 38.03 | ||
4 | 34.27±59.36 | 0.5, 70.13 | 16.60±14.58 | 0, 52.82 | ||
5 | 0 | - | 14.34±15.09 | 0, 149.95 | ||
BDNF – brain-derived neurotrophic factor; 95% CI – 95% confidence interval; SD – standard deviation; -value obtained by one-way ANOVA. |