Usefulness of Detecting Brain-Derived Neurotrophic Factor in Intervertebral Disc Degeneration of the Lumbosacral Spine

Rafał Staszkiewicz; Dorian Gładysz; Marcin Gralewski; Kamil Bryś; Michał Garczarek; Marcin Gadzieliński; Wiesław Marcol; Dawid Sobański; Beniamin Oskar Grabarek

doi:10.12659/MSM.938663

16 January 2023: Clinical Research

Usefulness of Detecting Brain-Derived Neurotrophic Factor in Intervertebral Disc Degeneration of the Lumbosacral Spine

Rafał Staszkiewicz ^12ABDEF* , Dorian Gładysz ^12ABDEF , Marcin Gralewski ^12DEF , Kamil Bryś ^2EF , Michał Garczarek ^1EF , Marcin Gadzieliński ^1EF , Wiesław Marcol ^34E , Dawid Sobański ^25B , Beniamin Oskar Grabarek ^12ACDEF

DOI: 10.12659/MSM.938663

Med Sci Monit 2023; 29:e938663

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Table 6 Changes in the concentration of BDNF in annulus fibrosus and nucleus pulposus in the control group.

Region of the IVD	Concentration of BDNF [pg/mg]		p-value
Region of the IVD	Mean±SD	95% CI	p-value
Annulus fibrosus	5.50±6.40	2.05, 8.95	0.010
Nucleus pulposus	0.55±2.08	0, 8.95	0.010
BDNF – brain-derived neurotrophic factor; 95% CI – 95% confidence interval; SD – standard deviation; -value determined by Student’s -test.

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Usefulness of Detecting Brain-Derived Neurotrophic Factor in Intervertebral Disc Degeneration of the Lumbosacral Spine

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