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04 March 2023: Clinical Research

Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study

Zejia Sun AEF* , Zihao Gao ACE* , Xin Li ABC* , Xiang Zheng BD , Wei Wang AEG#* , Peng Qiao AEF#*

DOI: 10.12659/MSM.938758

Med Sci Monit 2023; 29:e938758

Table 1 Kidney transplant recipient characteristics.

CharacteristicALL (n=102)DGF (n=14)NON-DGF (n=88)P valuea
Age, yr43.36±12.0739.97±11.2843.90±12.170.260
Male70 (68.6)13 (92.9)57 (64.8)0.059
BMI, kg/m23.32±3.7723.10±5.1923.36±3.530.857
Hypertension94 (92.2)11 (78.6)83 (94.3)0.077
Diabetes16 (15.7)1 (7.1)15 (17.0)0.691
Cause of ESRDGlomerulonephritis50 (49.0)7 (50.0)43 (48.9)0.976
Hypertension16 (15.7)2 (14.3)14 (15.9)
Diabetes12 (11.8)1 (7.1)11 (12.5)
Polycystic kidney6 (5.9)1 (7.1)5 (5.7)
Other or unknown18 (17.6)3 (21.4)15 (17.0)
HLA mismatch level02 (2.0)0 (0.0)2 (2.3)0.044
15 (4.9)0 (0.0)5 (5.7)
27 (6.9)0 (0.0)7 (8.0)
320 (19.6)1 (7.1)19 (21.6)
432 (31.4)2 (14.3)30 (34.1)
519 (18.6)5 (35.7)14 (15.9)
617 (16.7)6 (42.9)11 (12.5)
Panel reactive antibody0%65 (63.7)9 (64.3)56 (63.6)0.449
1–10%6 (5.9)2 (14.3)4 (4.5)
11–80%17 (16.7)2 (14.3)15 (17.0)
>80%14 (13.7)1 (7.1)13 (14.8)
Warm ischemia time, min2.68±0.062.64±0.172.68±0.060.754
Cold ischemia time, h6.71±1.928.33±1.706.42±1.79
Serum creatinine at transplant, mg/dl8.97±3.0610.05±2.808.80±3.080.155
Chronic dialysis before transplant82 (80.4)13 (92.9)69 (78.4)0.292
Allograft weight, g145.53±22.75149.00±14.94144.98±23.780.542
Perfusion time, min27.65±1.4528.00±1.1127.59±1.490.309
Immune inducerATG49 (48.0)8 (57.1)41 (46.6)0.264
Basiliximab50 (49.0)5 (35.7)45 (51.1)
ATG+ Basiliximab3 (2.9)1 (7.1)2 (2.3)
immunosuppressorTAC+MMF+PAT97 (95.1)14 (100.0)83 (94.3)0.470
CSA+MMF+PAT5 (4.9)0 (0.0)5 (5.7)
Values reported are the mean±SD, n(%), or as otherwise indicated.
a Wilcoxon rank-sum test or test was used for the continuous variables, and the chi-squared or Fisher exact tests were used for the categorical variables.
BMI – body mass index; ERSD – end-stage renal disease; HLA – human leukocyte antigen; ATG – antithymocyte globulin; TAC – tacrolimus; MMF – mycophenolate mofetil; CSA – cyclosporine; Pred – prednisone; DGF – delayed graft function.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750