04 March 2023 : Clinical Research
Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study
Zejia Sun1AEF, Zihao Gao1ACE, Xin Li1ABC, Xiang Zheng1BD, Wei Wang1AEG*, Peng Qiao1AEFDOI: 10.12659/MSM.938758
Med Sci Monit 2023; 29:e938758
Table 4 Performance indices of perfusate kidney injury biomarkers to diagnose DGF.
| Biomarker | Cut-off | C statistic (95% CI) | P value | Sensitivity | Specificity |
|---|---|---|---|---|---|
| NGAL (ng/ml) | 175.94 | 0.83 (0.70, 0.97) | <0.001 | 85.7% | 79.5% |
| L-FABP (ng/ml) | 1747.72 | 0.53 (0.37, 0.70) | 0.676 | 64.3% | 51.1% |
| KIM-1 (ng/ml) | 158.30 | 0.82 (0.70, 0.94) | <0.001 | 85.7% | 68.2% |
| IL-18 (pg/ml) | 178.68 | 0.57 (0.44, 0.71) | 0.381 | 55.7% | 70.0% |
| NGAL – Neutrophil gelatinase-associated lipocalin; L-FABP – liver-type fatty acid binding protein; KIM-1 – kidney injury molecular-1; IL-18 – interleukin-18; DGF – delayed graft function. | |||||