04 March 2023 : Clinical Research
Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study
Zejia Sun1AEF, Zihao Gao1ACE, Xin Li1ABC, Xiang Zheng1BD, Wei Wang1AEG*, Peng Qiao1AEFDOI: 10.12659/MSM.938758
Med Sci Monit 2023; 29:e938758
Table 5 Performance indices of perfusate NGAL, KIM-1, and serum creatinine reduction ratio to diagnose DGF.
| NGAL | KIM-1 | Creatinine reduction ratio | |
|---|---|---|---|
| Sensitivity | 0.8571 (0.5615, 0.9749) | 0.8571 (0.5615, 0.9749) | 0.7857 (0.4882, 0.9429) |
| Specificity | 0.7955 (0.6934, 0.8711) | 0.6818 (0.5728, 0.7748) | 0.9545 (0.8813, 0.9853) |
| True positive | 0.4000 (0.2322, 0.5925) | 0.3000 (0.1709, 0.4671) | 0.7333 (0.4483, 0.9109) |
| False positive | 0.6000 (0.4075, 0.7678) | 0.7000 (0.5329, 0.8291) | 0.2667 (0.0891, 0.5517) |
| True negative | 0.9722 (0.8942, 0.9952) | 0.9677 (0.8783, 0.9944) | 0.9655 (0.8955, 0.9911) |
| False negative | 0.0278 (0.0048, 0.1058) | 0.0323 (0.0056, 0.1217) | 0.0345 (0.0089, 0.1045) |
| Positive likelihood ratios | 4.1905 (2.6343, 6.6660) | 2.6939 (1.8548, 3.9125) | 17.2857 (6.3861, 46.7887) |
| Negative likelihood ratios | 0.1796 (0.0495, 0.6517) | 0.2095 (0.0575, 0.7638) | 0.2245 (0.0822, 0.6127) |
| NGAL – neutrophil gelatinase-associated lipocalin; KIM-1 – kidney injury molecular-1; DGF – delayed graft function. | |||