04 March 2023 : Clinical Research
Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study
Zejia Sun1AEF, Zihao Gao1ACE, Xin Li1ABC, Xiang Zheng1BD, Wei Wang1AEG*, Peng Qiao1AEFDOI: 10.12659/MSM.938758
Med Sci Monit 2023; 29:e938758
Table 7 Spearman correlations of 3-year graft survival, eGFR, urine albumin and perfusate kidney injury biomarkers in a random subcohort.
| Measure | NGAL (ng/ml) | L-FABP (ng/ml) | KIM-1 (ng/ml) | IL-18 (pg/ml) |
|---|---|---|---|---|
| 3-year graft survival | ||||
| Rho | −0.166 | −0.131 | −0.039 | 0.009 |
| value | 0.096 | 0.189 | 0.694 | 0.930 |
| 3-year eGFR (ml/min per 1.73 m) | ||||
| Rho | −0.208 | −0.071 | −0.260 | 0.006 |
| value | 0.036 | 0.476 | 0.008 | 0.955 |
| 3-year urine albumin (mg/dl) | ||||
| Rho | 0.150 | 0.148 | 0.134 | 0.067 |
| value | 0.132 | 0.138 | 0.180 | 0.505 |
| NGAL (ng/ml) | ||||
| Rho | 0.193 | 0.185 | 0.170 | |
| value | 0.052 | 0.062 | 0.088 | |
| L-FABP (ng/ml) | ||||
| Rho | 0.029 | 0.056 | ||
| value | 0.770 | 0.573 | ||
| KIM-1 (ng/ml) | ||||
| Rho | 0.058 | |||
| value | 0.562 | |||
| NGAL – neutrophil gelatinase-associated lipocalin; L-FABP – liver-type fatty acid binding protein; KIM-1 – kidney injury molecular-1; IL-18 – interleukin-18; eGFR – estimated glomerular filtration rate. | ||||