06 February 2023: Database Analysis
Comparison of Neonatal Morbidity and Mortality Following Spontaneous and Medically Indicated Preterm Births: A Retrospective Population-Based Study Using Data from the Slovenian National Perinatal Information System 2013–2018
Katja Čehovin 1DEF* , Ajda Gortnar 2DEF* , Ivan Verdenik 3ABCD , Miha Lučovnik 34ACDE , Lilijana Kornhauser-Cerar 3ACDE , Štefan Grosek 356ACDEFG*DOI: 10.12659/MSM.938941
Med Sci Monit 2023; 29:e938941
Table 1 Neonatal outcomes according to type of preterm birth at GA 22 0/7 to 31 6/7 weeks.
| Spontaneous preterm birth N (%) | Medically indicated preterm birth N (%) | OR (95% CI)* | Adjusted OR (95% CI) multivariate analysis** | |
|---|---|---|---|---|
| Neonatal mortality | 37 (3.7%) | 22 (6.1%) | 0.59 [0.33–1.02] | 0.34 [0.14–0.81] |
| IVH | 57 (5.7%) | 9 (2.5%) | 2.36 [1.16–4.82] | 1.10 [0.43–2.82] |
| cPVL | 17 (1.7%) | 6 (1.7%) | 1.02 [0.40–2.61] | 0.89 [0.25–3.16] |
| BPD | 158 (15.8%) | 64 (17.8%) | 0.87 [0.63–1.20] | 0.81 [0.51–1.29] |
| NEC | 36 (3.6%) | 21 (5.8%) | 0.60 [0.35–1.05] | 0.51 [0.22–1.18] |
| LOS | 50 (5.0%) | 13 (3.6%) | 2,42 [0.76–2.62] | 1.89 [0.81–4.44] |
| ROP | 79 (7.9%) | 35 (9.7%) | 0.80 [0.53–1.21] | 0.33 [0.17–0.63] |
| Composite neonatal morbidity | 269 (27.0%) | 104 (28.9%) | 0.91 [0.70–1.19] | 0.71 [0.47–1.07] |
| IVH – intraventricular hemorrhage (Papile grade 3 or 4); cPVL – cystic periventricular leukomalacia; BPD – bronchopulmonary dysplasia; NEC – necrotizing enterocolitis; LOS – late-onset neonatal sepsis; ROP – retinopathy of prematurity, composite neonatal morbidity defined as any of the conditions above. * Univariate analysis odds ratio. ** Multivariate analysis odds ratio: adjusted for small for gestational age (SGA – defined as neonatal weight 37 years, maternal body-mass-index (BMI) >30 kg/m, in vitro fertilization (IVF) and gestation (22 0/7 to 27 6/7 vs 28 0/7 to 31 6/7 weeks). | ||||