20 January 2023>: Clinical Research
Monitoring of Autoantibodies Following Autologous Hematopoietic Stem Cell Transplantation in 6 Children with Recently Diagnosed Type 1 Diabetes Mellitus
Alejandro D. Mesples 1ABCDEFG* , Desiree C.T. Cox 23ACDEF , Harriet D. Lundy 1ADE , Sheena Antonio-Collie 1CDG , Charles W. Diggis 1A , Jonathan R.T. Lakey 4ACDEFDOI: 10.12659/MSM.938979
Med Sci Monit 2023; 29:e938979
Table 2 Variables analyzed in the 6-month follow-up of patients with autoimmune diabetes who received an autologous bone marrow stem cell transplant.
Patient age (years) | Ins dose (units) | A1c (%) | Creatinine (mg/dl) | Glyc. control (mg/dl) | C peptide (ng/mL) | ICA (JDF units) | GAD (units/ml) | IA2 (units/ml) | INS AB (units/ml) | |
---|---|---|---|---|---|---|---|---|---|---|
Patient 1 | 8 | 10 | 6 | 0.8 | 1.9 | 0 | 100 | 10 | 18 | |
Patient 2 | 7 | 20 | 6 | 0.9 | 1.1 | 0 | 209 | 10 | 11 | |
Patient 3 | 9 | 40 | 9 | 0.9 | 150–250 | 13 | 250 | 170 | 20 | |
Patient 4 | 10 | 10 | 6 | 1.1 | 1.5 | 0 | 198 | 5 | 10 | |
Patient 5 | 6 | 6 | 6 | 0.7 | 0.7 | 0 | 60 | 20 | 7 | |
Patient 6 | 7 | 20 | 6 | 0.9 | 0 | 87 | 10 | 12 | ||
ABMHSC – autologous bone marrow hematopoietic stem cells; Ins Dose – insulin daily dose; A1C – glycosylated hemoglobin A1c; Glyc. Control – glycemic control; ICA – islet cell antibodies; IA2– antibodies against islet antigen-related tyrosine phosphatase 2; GAD – glutamic acid-decarboxylase; AIA – antibodies, anti-insulin antibodies. |