09 July 2023: Clinical Research
Dysregulation of Inflammation, Oxidative Stress, and Glucose Metabolism-Related Genes and miRNAs in Visceral Adipose Tissue of Women with Type 2 Diabetes Mellitus
Adam Wróblewski 1ABCDEF** , Justyna Strycharz 1ABCDEF* , Katarzyna Oszajca 1CE , Piotr Czarny 1E , Ewa Świderska 1BEF , Tomasz Matyjas 2EF , Andrzej Zieleniak 3CE , Monika Rucińska 2EF , Lech Pomorski 2E , Józef Drzewoski 4EG , Agnieszka Śliwińska 5AEG , Janusz Szemraj 1AEGDOI: 10.12659/MSM.939299
Med Sci Monit 2023; 29:e939299
Table 1 A list of studied miRNAs and their target genes.
| miRNAs | Target genes | Modulatory molecules | Examined cell lines/tissues | References |
|---|---|---|---|---|
| let-7g-5p | C2C12 myoblasts (murine) | []20 | ||
| miR-10b-5p | – | NF-κB | MDA-MB-231 breast tumor cells; HCT116 colon tumor cells (human) | []21 |
| miR-132-3p | Primary rat cardiac fibroblasts | []22 | ||
| miR-145-5p | Ipsilateral cortical tissue (rat) | []23 | ||
| miR-16-5p | Human glioma cell lines | []24 | ||
| miR-20a-5p | Human cardiac fibroblasts | []25 | ||
| miR-21-5p | NF-κB | HEK293 cells; H9c2 cardiomyoblasts; MDA-MB-231 breast tumor cells; HCT116 colon tumor cells (human) | [,]21 | |
| miR-214-3p | Mesenchymal stem cells; C2C12 myoblasts (murine) | [,]27 | ||
| miR-222-3p | HEK293 cells; H9c2 cardiomyoblasts | []26 | ||
| miR-26a-5p# | Glioblastoma multiforme U87 cells | []29 | ||
| miR-26b-5p# | ** | Granulosa cells (porcine) | []30 | |
| miR-374a-5p | Head and neck squamous cell carcinoma (HNSCC) cells | []31 | ||
| miR-93-3p | – | |||
| miR-99b-5p | – | NF-κB | MH-S macrophages | []32 |
| * Targets predicted by Targetscan []; ** targets predicted by miRTarbase and miRTargetLink Human [,]; # miRNAs investigated only in ex vivo study, which expression in HPA-vs we had reported previously []. | ||||