09 July 2023 : Clinical Research
Dysregulation of Inflammation, Oxidative Stress, and Glucose Metabolism-Related Genes and miRNAs in Visceral Adipose Tissue of Women with Type 2 Diabetes Mellitus
Adam Wróblewski
1ABCDEF*, Justyna Strycharz 1ABCDEF, Katarzyna Oszajca 1CE, Piotr Czarny 1E, Ewa Świderska 1BEF, Tomasz Matyjas2EF, Andrzej Zieleniak 3CE, Monika Rucińska2EF, Lech Pomorski 2E, Józef Drzewoski 4EG, Agnieszka Śliwińska 5AEG, Janusz Szemraj 1AEG
DOI: 10.12659/MSM.939299
Med Sci Monit 2023; 29:e939299
Table 4 In silico analysis involving 5 upregulated miRNAs (miR-10b-5p, miR-132-3p, miR-20a-5p, miR-21-5p, and miR-26a-5p) in VAT of T2DM female subjects based on miEAA (WikiPathways, miRPathDB). Only significant records are shown (P<0.05), for at least 4 union miRNAs.
| Subcategory | Adjusted P | Q-value | miRNAs |
|---|---|---|---|
| Androgen receptor signaling pathway | 0.0020532 | 0.0020532 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5p; hsa-miR-26a-5p |
| Adipogenesis | 0.0044093 | 0.0044093 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5p; hsa-miR-26a-5p |
| Aryl hydrocarbon receptor | 0.00429 | 0.00429 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5p |
| ESC pluripotency pathways | 0.00429 | 0.00429 | hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5p; hsa-miR-26a-5p |
| Signaling pathways in glioblastoma | 0.00429 | 0.00429 | hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5p; hsa-miR-26a-5p |
| Photodynamic therapy-induced AP-1 survival signaling | 0.0087179 | 0.0087179 | hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5p; hsa-miR-26a-5p |
| Integrated cancer pathway | 0.0108058 | 0.0108058 | hsa-miR-10b-5p; hsa-miR-20a-5p; hsa-miR-21-5p; hsa-miR-26a-5p |
| Breast cancer pathway | 0.0114399 | 0.0114399 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-21-5p; hsa-miR-26a-5p |
| G1 to S cell cycle control | 0.0114399 | 0.0114399 | hsa-miR-10b-5p; hsa-miR-20a-5p; hsa-miR-21-5p; hsa-miR-26a-5p |
| Integrated breast cancer pathway | 0.0114986 | 0.0114986 | hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5p; hsa-miR-26a-5p |
| Pancreatic adenocarcinoma pathway | 0.0114986 | 0.0114986 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5 |
| Retinoblastoma gene in cancer | 0.0114986 | 0.0114986 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5 |
| miRNA regulation of DNA damage response | 0.0114986 | 0.0114986 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5 |
| Cell cycle | 0.0126161 | 0.0126161 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5 |
| DNA damage response only ATM dependent | 0.0177883 | 0.0177883 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5 |
| Retinoblastoma gene in cancer | 0.0114986 | 0.0114986 | hsa-miR-10b-5p; hsa-miR-132-3p; hsa-miR-20a-5p; hsa-miR-21-5 |