09 July 2023: Clinical Research
Dysregulation of Inflammation, Oxidative Stress, and Glucose Metabolism-Related Genes and miRNAs in Visceral Adipose Tissue of Women with Type 2 Diabetes Mellitus
Adam Wróblewski 1ABCDEF** , Justyna Strycharz 1ABCDEF* , Katarzyna Oszajca 1CE , Piotr Czarny 1E , Ewa Świderska 1BEF , Tomasz Matyjas 2EF , Andrzej Zieleniak 3CE , Monika Rucińska 2EF , Lech Pomorski 2E , Józef Drzewoski 4EG , Agnieszka Śliwińska 5AEG , Janusz Szemraj 1AEGDOI: 10.12659/MSM.939299
Med Sci Monit 2023; 29:e939299
Supplementary Table 2 Mean or median 2^-ΔCt values found for tested miRNAs and genes in VAT of male study subjects. Median was calculated for let-7g-5p, miR-20a-5p, miR-222-3p, miR-26b-5p, miR-374a-5p, miR-99b-5p and ATM. None of tested molecules was significantly changed.
| miRNA | NGM (2^-ΔCt) | IFG (2^-ΔCt) | T2DM (2^-ΔCt) |
|---|---|---|---|
| let-7g-5p | 0.559 | 0.507 | 0.389 |
| miR-10b-5p | 0.113 | 0.101 | 0.248 |
| miR-132-3p | 0.089 | 0.124 | 0.117 |
| miR-145-5p | 4.584 | 5.457 | 4.769 |
| miR-16-5p | 10.273 | 12.564 | 14.291 |
| miR-20a-5p | 0.744 | 0.663 | 0.561 |
| miR-21-5p | 0.162 | 0.168 | 0.106 |
| miR-214-3p | 0.359 | 0.283 | 0.414 |
| miR-222-3p | 2.426 | 2.991 | 3.483 |
| miR-26a-5p | 1.985 | 1.956 | 1.752 |
| miR-26b-5p | 0.805 | 0.756 | 0.795 |
| miR-374a-5p | 0.296 | 0.340 | 0.310 |
| miR-93-3p | 0.081 | 0.092 | 0.104 |
| miR-99b-5p | 0.093 | 0.079 | 0.081 |
| ATM | 0.093 | 0.079 | 0.081 |
| NFKB1 | 0.030 | 0.018 | 0.015 |
| SOD2 | 0.234 | 0.144 | 0.216 |
| INSR | 0.645 | 0.403 | 0.589 |
| TIGAR | 0.095 | 0.117 | 0.061 |