09 July 2023 : Clinical Research
Dysregulation of Inflammation, Oxidative Stress, and Glucose Metabolism-Related Genes and miRNAs in Visceral Adipose Tissue of Women with Type 2 Diabetes Mellitus
Adam Wróblewski
1ABCDEF*, Justyna Strycharz 1ABCDEF, Katarzyna Oszajca 1CE, Piotr Czarny 1E, Ewa Świderska 1BEF, Tomasz Matyjas2EF, Andrzej Zieleniak 3CE, Monika Rucińska2EF, Lech Pomorski 2E, Józef Drzewoski 4EG, Agnieszka Śliwińska 5AEG, Janusz Szemraj 1AEG
DOI: 10.12659/MSM.939299
Med Sci Monit 2023; 29:e939299
Supplementary Table 3 Top 25 results of in silico analysis of 5 upregulated miRNAs in VAT of T2DM females by miRSystem.
| Category | Term | Target genes | Union miRNAs | Rawp value | Empiricalp value |
|---|---|---|---|---|---|
| PAD | DIRECT_P53_EFFECTORS | 11 | 5 | 5.67492e-7 | 1.56250e-4 |
| REACTOME | SIGNALING_BY_FGFR | 8 | 5 | 5.08962e-5 | 1.66944e-4 |
| REACTOME | DOWNSTREAM_SIGNAL_TRANSDUCTION | 8 | 5 | 1.19739e-5 | 2.09907e-4 |
| KEGG | MELANOMA | 6 | 5 | 1.62297e-4 | 2.34631e-4 |
| BIOCARTA | BIOCARTA_MET_PATHWAY | 5 | 5 | 6.29457e-5 | 2.57466e-4 |
| KEGG | CELL_CYCLE | 9 | 4 | 1.34685e-5 | 5.04371e-4 |
| PAD | LPA_RECEPTOR_MEDIATED_EVENTS | 6 | 4 | 1.09058e-4 | 5.90783e-4 |
| KEGG | PROSTATE_CANCER | 7 | 5 | 7.35111e-5 | 1.02543e-3 |
| REACTOME | DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR | 7 | 5 | 1.50534e-4 | 1.24911e-3 |
| REACTOME | SIGNALING_BY_PDGF | 8 | 5 | 8.12622e-5 | 1.25268e-3 |
| REACTOME | PI-3K_CASCADE | 5 | 5 | 4.80022e-4 | 1.67384e-3 |
| REACTOME | METABOLISM_OF_MRNA | 10 | 4 | 2.02327e-4 | 2.24215e-3 |
| PAD | PDGFR-BETA_SIGNALING_PATHWAY | 8 | 5 | 1.01250e-4 | 2.48393e-3 |
| REACTOME | GAB1_SIGNALOSOME | 4 | 5 | 9.96379e-4 | 2.89389e-3 |
| PAD | P53_PATHWAY | 7 | 4 | 4.57639e-6 | 3.01624e-3 |
| PAD | SIGNALING_EVENTS_MEDIATED_BY_FOCAL_ADHESION_KINASE | 6 | 5 | 5.32653e-5 | 3.24343e-3 |
| KEGG | FC_GAMMA_R-MEDIATED_PHAGOCYTOSIS | 6 | 4 | 7.08032e-4 | 3.87075e-3 |
| KEGG | TGF-BETA_SIGNALING_ PATHWAY | 7 | 5 | 5.11750e-5 | 3.95928e-3 |
| KEGG | MAPK_SIGNALING_ PATHWAY | 12 | 5 | 7.09942e-5 | 4.48920e-3 |
| REACTOME | P53-DEPENDENT_G1_DNA_DAMAGE_RESPONSE | 5 | 4 | 4.80022e-4 | 5.14772e-3 |
| REACTOME | P53-DEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT | 5 | 4 | 4.80022e-4 | 5.14772e-3 |
| REACTOME | PI3K_AKT_ACTIVATION | 4 | 5 | 8.18809e-4 | 5.54382e-3 |
| REACTOME | G1_S_DNA_DAMAGE_ CHECKPOINTS | 5 | 4 | 6.04808e-4 | 6.04027e-3 |
| KEGG | PATHWAYS_IN_CANCER | 12 | 5 | 3.43108e-4 | 6.89897e-3 |
| REACTOME | DNA_REPLICATION | 8 | 4 | 1.90193e-3 | 7.67472e-3 |
| PAD – pathway interaction database; KEGG – Kyoto Encyclopedia of Genes and Genomes. | |||||