09 July 2023: Clinical Research
Dysregulation of Inflammation, Oxidative Stress, and Glucose Metabolism-Related Genes and miRNAs in Visceral Adipose Tissue of Women with Type 2 Diabetes Mellitus
Adam Wróblewski 1ABCDEF** , Justyna Strycharz 1ABCDEF* , Katarzyna Oszajca 1CE , Piotr Czarny 1E , Ewa Świderska 1BEF , Tomasz Matyjas 2EF , Andrzej Zieleniak 3CE , Monika Rucińska 2EF , Lech Pomorski 2E , Józef Drzewoski 4EG , Agnieszka Śliwińska 5AEG , Janusz Szemraj 1AEGDOI: 10.12659/MSM.939299
Med Sci Monit 2023; 29:e939299
Supplementary Table 3 Top 25 results of in silico analysis of 5 upregulated miRNAs in VAT of T2DM females by miRSystem.
| Category | Term | Target genes | Union miRNAs | Rawp value | Empiricalp value |
|---|---|---|---|---|---|
| PAD | DIRECT_P53_EFFECTORS | 11 | 5 | 5.67492e-7 | 1.56250e-4 |
| REACTOME | SIGNALING_BY_FGFR | 8 | 5 | 5.08962e-5 | 1.66944e-4 |
| REACTOME | DOWNSTREAM_SIGNAL_TRANSDUCTION | 8 | 5 | 1.19739e-5 | 2.09907e-4 |
| KEGG | MELANOMA | 6 | 5 | 1.62297e-4 | 2.34631e-4 |
| BIOCARTA | BIOCARTA_MET_PATHWAY | 5 | 5 | 6.29457e-5 | 2.57466e-4 |
| KEGG | CELL_CYCLE | 9 | 4 | 1.34685e-5 | 5.04371e-4 |
| PAD | LPA_RECEPTOR_MEDIATED_EVENTS | 6 | 4 | 1.09058e-4 | 5.90783e-4 |
| KEGG | PROSTATE_CANCER | 7 | 5 | 7.35111e-5 | 1.02543e-3 |
| REACTOME | DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR | 7 | 5 | 1.50534e-4 | 1.24911e-3 |
| REACTOME | SIGNALING_BY_PDGF | 8 | 5 | 8.12622e-5 | 1.25268e-3 |
| REACTOME | PI-3K_CASCADE | 5 | 5 | 4.80022e-4 | 1.67384e-3 |
| REACTOME | METABOLISM_OF_MRNA | 10 | 4 | 2.02327e-4 | 2.24215e-3 |
| PAD | PDGFR-BETA_SIGNALING_PATHWAY | 8 | 5 | 1.01250e-4 | 2.48393e-3 |
| REACTOME | GAB1_SIGNALOSOME | 4 | 5 | 9.96379e-4 | 2.89389e-3 |
| PAD | P53_PATHWAY | 7 | 4 | 4.57639e-6 | 3.01624e-3 |
| PAD | SIGNALING_EVENTS_MEDIATED_BY_FOCAL_ADHESION_KINASE | 6 | 5 | 5.32653e-5 | 3.24343e-3 |
| KEGG | FC_GAMMA_R-MEDIATED_PHAGOCYTOSIS | 6 | 4 | 7.08032e-4 | 3.87075e-3 |
| KEGG | TGF-BETA_SIGNALING_ PATHWAY | 7 | 5 | 5.11750e-5 | 3.95928e-3 |
| KEGG | MAPK_SIGNALING_ PATHWAY | 12 | 5 | 7.09942e-5 | 4.48920e-3 |
| REACTOME | P53-DEPENDENT_G1_DNA_DAMAGE_RESPONSE | 5 | 4 | 4.80022e-4 | 5.14772e-3 |
| REACTOME | P53-DEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT | 5 | 4 | 4.80022e-4 | 5.14772e-3 |
| REACTOME | PI3K_AKT_ACTIVATION | 4 | 5 | 8.18809e-4 | 5.54382e-3 |
| REACTOME | G1_S_DNA_DAMAGE_ CHECKPOINTS | 5 | 4 | 6.04808e-4 | 6.04027e-3 |
| KEGG | PATHWAYS_IN_CANCER | 12 | 5 | 3.43108e-4 | 6.89897e-3 |
| REACTOME | DNA_REPLICATION | 8 | 4 | 1.90193e-3 | 7.67472e-3 |
| PAD – pathway interaction database; KEGG – Kyoto Encyclopedia of Genes and Genomes. | |||||