12 April 2023: Clinical Research
Clinical Evaluation of Continuous Renal Replacement Therapy Combined with Peritoneal Lavage for Severe Acute Pancreatitis: A Retrospective Cohort Study
Wen-zhu Jiang 1EF , Hong-jie Zhao 2BC , Lu Chen 3DF , Xiao-dong Tang 3DF , Zhi-cheng Deng 3AE*DOI: 10.12659/MSM.939314
Med Sci Monit 2023; 29:e939314
Table 1 Patients’ baseline characteristics.
| Combined group (n=26) | CRRT group (n=26) | P | |
|---|---|---|---|
| Age (years) | 42.3±11.8 | 43.6±12.1 | 0.696 |
| Sex | 0.776 | ||
| Female | 16 (61.5%) | 15 (57.7%) | |
| Male | 10 (38.5%) | 11 (42.3%) | |
| Cause of pancreatitis | 0.822 | ||
| Gallstones | 12 (46.2%) | 15 (57.7%) | |
| Alcohol abuse | 4 (15.4%) | 4 (15.4%) | |
| Hyperlipidemia | 6 (23.1%) | 5 (19.2%) | |
| Others | 4 (15.4%) | 2 (7.6%) | |
| Creatinine (umol/L | 135.2±25.7 | 128.1±30.1 | 0.365 |
| Serum amylase (IU/L) | 869.3±115.2 | 871.8±123.6 | 0.947 |
| Total bilirubin (mmol/L) | 48.3±23.7 | 47.3±28.6 | 0.891 |
| Procalcitonin (ng/mL) | 23.5±6.8 | 22.3±5.4 | 0.484 |
| Interleukin-6 (pg/mL) | 982.3±128.9 | 997.5±162.3 | 0.710 |
| C-reactive protein (mg/L) | 269.7±54.4 | 252.6±68.5 | 0.324 |
| Triglyceride (mmol/L) | 8.6±3.7 | 8.7±4.6 | 0.932 |
| APACHE-II score (at admission) | 9.3±5.1 | 9.5±4.9 | 0.886 |
| Ranson score (at admission) | 3.2±1.1 | 3.3±1.2 | 0.755 |
| CT Severity Index score (at admission)* | 6±2 | 7±2 | 0.078 |
| Multiple organ failure (at admission) | 5 (19.2%) | 6 (23.1%) | 0.734 |
| Combined group received continuous renal replacement therapy (CCRT) combined with peritoneal lavage. Data are shown as median (range) or number (percentage) or stated otherwise. * Data were derived from contrast-enhanced computed tomography (CT) performed before patients underwent randomization. Scores on the CT Severity Index range from 0 to 10, with higher scores indicating more extensive pancreatic and peripancreatic necrosis. | |||