27 July 2023: Clinical Research
Factors Associated with Severe Adenovirus Pneumonia in Children: A Retrospective Study from Guangzhou, China (2017–2019)
Yan Hong ABCDEF , Qiang Wang BCE , Yongling Song BCE , Guangming Liu BCDE , Jun Shen ACDEG*DOI: 10.12659/MSM.939578
Med Sci Monit 2023; 29:e939578
Table 5 Laboratory findings of hospitalized children with severe adenovirus pneumonia.
| Laboratory data | Total | Mild group | Severe group | P value | |
|---|---|---|---|---|---|
| Blood culture (%) | 0 | 169 (97.69) | 116 (99.15) | 53 (94.64) | 0.065 |
| 1 | 4 (2.31) | 1 (0.85) | 3 (5.36) | ||
| Sputum culture (%)a | 0 | 119 (68.79) | 89 (76.07) | 30 (53.57) | 0.003 |
| 1 | 54 (31.21) | 28 (23.93) | 26 (46.63) | ||
| Other pathogens (%)b | 0 | 117 (67.63) | 75 (64.10) | 42 (75. 00) | 0.152 |
| 1 | 56 (32.37) | 42 (35.90) | 14 (25.00) | ||
| WBC (χ̄±S) | 10.32±5.51 | 11.16±5.79 | 8.56±4.43 | 0.003 | |
| N (χ̄±S) | 6.44±5.84 | 6.96±6.46 | 5.36±4.09 | 0.093 | |
| Hb (χ̄±S) | 111.88±13.45 | 114.42±12.23 | 106.58±14.42 | 0.054 | |
| PLT (IQR) | 299.5 (210.5, 402.75) | 225.25 (310.50, 429.75) | 276.5 (191.5, 360.25) | 0.062 | |
| AST (IQR) | 17 (12, 24.5) | 16 (12, 23) | 19 (13, 29) | 0.113 | |
| ALT (IQR) | 47 (33.75, 73.25) | 43 (30, 56) | 72 (39, 118) | 0.000 | |
| LDH (IQR) | 407 (292.5, 639.75) | 342 (274, 539) | 642 (403, 1275) | 0.000 | |
| Albumin (g/l) (χ̄±S) | 37.12±5.04 | 38.6±4.21 | 34.09±5.28 | 0.000 | |
| CK-MB (IQR) | 25 (20, 31) | 20 (23, 30) | 27 (19.5, 38.75) | 0.012 | |
| CRP (IQR) | 18.59 (7.89, 32.66) | 18.90 (7.57, 31.33) | 17.96 (8.24, 38.32) | 0.831 | |
| Infiltrates±consolidation | 0 | 119 (68.79) | 100 (85.47) | 19 (33.93) | 0.000 |
| (%) | 1 | 54 (31.21) | 17 (14.53) | 37 (66.07) | |
| a Sputum culture: 28 cases of mild patients were accompanied by bacterial infections, of which 10 cases were infected with haemophilus influenzae, 2 cases of pseudomonas aeruginosa, 12 S. pneumoniae, 1 streptococcus agalactiae, 1 moraxella catarrhalis, two cases of co-infection. 26 severe patients were infected with more bacteria, 1 case of acinetobacter janeii, 11 haemophilus influenzae, 4 S. pneumoniae, 2 klebsiella pneumoniae, 1 moraxella catarrhalis, 1 stenotrophomonas maltophilia, 2 staphylococcus aureus, 3 cases of co-infection; b Other viral pathogens: the main co-infecting microorganism in mild infection and severe infection both was M. pneumoniae, 32 and 11 cases, respectively. IQR – interquartile range. | |||||