11 May 2023 : Clinical Research
Hippocampal Metabolic Alterations and Cognitive Dysfunction in Varicella Zoster Virus Meningitis: A Single-Center Case Series Study
Huili Liu1ABEF, Jun Wang1BCDE, Yanrong Yuan1BCF, Jing Gu1BCF, Yongxing Yan1ACDEG*DOI: 10.12659/MSM.939670
Med Sci Monit 2023; 29:e939670
Table 1 Baseline characteristics of patients in the 2 groups on admission.
| VZV meningitis group (n=23) | Control group (n=19) | t/χ2 | P | |
|---|---|---|---|---|
| Age (mean±SD; years) | 56.0±15.3 | 56.2±20.3 | 0.03 | 0.98 |
| Sex | ||||
| Male (number, %) | 16 (69.6%) | 11 (57.9%) | 0.62 | 0.43 |
| Female (number, %) | 7 (30.4%) | 8 (42.1%) | ||
| Years of education (mean±SD; years) | 8.57±4.70 | 8.68±3.73 | 0.09 | 0.93 |
| Comorbidity (cases) | ||||
| Hypertension | 9 | 5 | 0.77 | 0.38 |
| Diabetes | 1 | 1 | 0.02 | 0.89 |
| Stroke | 1 | 3 | 1.58 | 0.21 |
| Coronary heart disease | 1 | 1 | 0.02 | 0.89 |
| COPD | 2 | 1 | 0.18 | 0.67 |
| Immune diseases | 2 | 1 | 0.18 | 0.67 |
| Use of immune drugs | 1 | 1 | 0.02 | 0.89 |
| Tumor | 2 | 1 | 0.18 | 0.67 |
| Herpes zoster site (number) | ||||
| Head and face | 18 | NA | ||
| Neck | 2 | NA | ||
| Chest and back | 3 | NA | ||
| Waist | 1 | NA | ||
| Limb | 1 | NA | ||
| CSF | ||||
| WBC count (×10/L) | 13 (5.82) | NA | ||
| Protein (mg/dL) | 64.61±31.22 | NA | ||
| Glucose (mmol/L) | 3.86±0.71 | NA | ||
| Chlorine (mmol/L) | 124.5±3.65 | NA | ||
| ADA (U/L) | 1.68±1.04 | NA | ||
| LDH (U/L) | 34.30±15.56 | NA | ||
| VZV – varicella zoster virus; COPD – chronic obstructive pulmonary disease; NA – not applicable; CSF – cerebrospinal fluid; WBC – white blood cells; ADA – adenosine deaminase; LDH – lactate dehydrogenase. | ||||