14 October 2023 : Clinical Research
Influence of Age, Gender, Frailty, and Body Mass Index on Serum IL-17A Levels in Mature Type 2 Diabetic Patients
Zvonimir Bosnić1ABEF, František Babič
2CDEG*, Thomas Wittlinger34DEG, Viera Anderková2C, Ines Šahinović 5B, Ljiljana Trtica Majnarić16ABDEF
DOI: 10.12659/MSM.940128
Med Sci Monit 2023; 29:e940128
Table 6 Multinomial logistic regression models for quartiles of IL-17A. All models were adjusted for age, sex, T2D duration, and frailty index.
| Model “Markers of inflammation”: variables in the input: Leukocyte number, Haemoglobin, and CRP; AIC: 488.37. | ||||||
|---|---|---|---|---|---|---|
| Quartile 2 | Quartile 3 | Quartile 4 | ||||
| z-value | OR (95% CI) | z-value | OR (95% CI) | z-value | OR (95% CI) | |
| Haemoglobin (g/l) | 2.06 (p-value 0.04) | 1.05 (1.01–1.09) | ||||
| Model “Anthropometric measures”: variables in the input: BMI, wc; AIC: 505.80. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Other prescribed drugs”: variables in the input: NSAID, ACE-INH/ARBs, Calcium channel blockers, Beta-blockers, Diuretics, Statins; AIC: 498.77. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Cardio-metabolic comorbidities”: variables in the input: CAD, CHD, retinopathy, smoking habit, Metabolic Syndrome; AIC: 502.08. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. | ||||||
| Model “Laboratory tests”: variables in the input: eGFR, HbA1C, Triglycerides, HDL-cholesterol, TSH; AIC: 500.67. | ||||||
| Quartile 2 | Quartile 3 | Quartile 4 | ||||
| z-value | OR (95% CI) | z-value | OR (95% CI) | z-value | OR (95% CI) | |
| HbA1C (%) | 1.93 (p-value 0.05) | 1.45 (1.00–2.00) | ||||
| Model “Anthropometric measures”: variables in the input: BMI, wc; AIC: 505.80. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Other prescribed drugs”: variables in the input: NSAID, ACE-INH/ARBs, Calcium channel blockers, Beta-blockers, Diuretics, Statins; AIC: 498.77. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Cardio-metabolic comorbidities”: variables in the input: CAD, CHD, retinopathy, smoking habit, Metabolic Syndrome; AIC: 502.08. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. | ||||||
| Model “Other comorbidities”: variables in the input: osteoporosis, osteoarthritis, low back pain, anxiety/depression, COPD/asthma, gastro-intestinal disorders, thyroid gland disorders, urogenital disease; AIC: 471.67. | ||||||
| Quartile 2 | Quartile 3 | Quartile 4 | ||||
| z-value | OR (95% CI) | z-value | OR (95% CI) | z-value | OR (95% CI) | |
| Osteoporosis = yes | 2.36 (p-value 0.02) | 10.10 (2.01–50.66) | ||||
| Osteoarthritis = yes | −2.17 (p-value 0.04) | 0.21 (0.06–0.69) | ||||
| Urogenital dis. = yes | −2.18 (p-value 0.02) | 0.19 (0.06–0.66) | ||||
| Frailty status = pre-frail | −2.25 (p-value 0.04) | 0.16 (0.04–0.61) | ||||
| Model “Anthropometric measures”: variables in the input: BMI, wc; AIC: 505.80. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Other prescribed drugs”: variables in the input: NSAID, ACE-INH/ARBs, Calcium channel blockers, Beta-blockers, Diuretics, Statins; AIC: 498.77. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Cardio-metabolic comorbidities”: variables in the input: CAD, CHD, retinopathy, smoking habit, Metabolic Syndrome; AIC: 502.08. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. | ||||||
| Model “Comorbidity level and functional disorders”: variables in the input: frailty index (0,1,2), nutritional status, incontinentio urinae, number of comorbidities, and number of medications prescribed; AIC: 494.51. | ||||||
| Quartile 2 | Quartile 3 | Quartile 4 | ||||
| z-value | OR (95% CI) | z-value | OR (95% CI) | z-value | OR (95% CI) | |
| Frailty status = pre-frail | −1.92 (p-value 0.05) | 0.30 (0.11–0.84) | ||||
| Model “Anthropometric measures”: variables in the input: BMI, wc; AIC: 505.80. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Other prescribed drugs”: variables in the input: NSAID, ACE-INH/ARBs, Calcium channel blockers, Beta-blockers, Diuretics, Statins; AIC: 498.77. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Cardio-metabolic comorbidities”: variables in the input: CAD, CHD, retinopathy, smoking habit, Metabolic Syndrome; AIC: 502.08. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. | ||||||
| Model “Antidiabetic drugs”: variables in the input: metformin, sulfonylureas, pioglitazone, DPP4inh, GLP1ra, SGLT2inh, insulin therapy; AIC: 507.85. | ||||||
| Quartile 2 | Quartile 3 | Quartile 4 | ||||
| z-value | OR (95% CI) | z-value | OR (95% CI) | z-value | OR (95% CI) | |
| Pioglitazone = yes | −1.98 (p-value 0.04) | 0.06 (0.01–0.62) | ||||
| DPP4inh = yes | −2.41 (p-value 0.04) | 0.08 (0.02–0.46) | ||||
| Model “Anthropometric measures”: variables in the input: BMI, wc; AIC: 505.80. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Other prescribed drugs”: variables in the input: NSAID, ACE-INH/ARBs, Calcium channel blockers, Beta-blockers, Diuretics, Statins; AIC: 498.77. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. Model “Cardio-metabolic comorbidities”: variables in the input: CAD, CHD, retinopathy, smoking habit, Metabolic Syndrome; AIC: 502.08. These variables did not show a significant relation with the output variable (quartiles of IL-17A), all p-values higher than 0.05. | ||||||