21 May 2023 : Clinical Research
Value of IL-1β and IL-23 in Predicting 28-Day Mortality Due to Sepsis: A Retrospective Study
Jing Cao1ABE*, Wenguang Liu1CDE, Yong Li1ABF, Bin Chen1CDE, Tingfeng Yu1DEF, Zhengbing He1BCD, Yanke Hong1EFDOI: 10.12659/MSM.940163
Med Sci Monit 2023; 29:e940163
Table 1 Comparison of clinical indicators in the septic patients, ICU controls, and healthy controls.
| Healthy controls (n=50) | ICU controls (n=45) | Septic patients (n=74) | Z/χ2 | P value | |
|---|---|---|---|---|---|
| Age, years [median (IQR)] | 54.5 (45.5–67.0) | 61.0 (52.5–68.0) | 56.0 (43.0–68.0) | 2.878 | 0.237 |
| Male sex (n, %) | 29 (58.00%) | 29 (64.44%) | 55 (74.32%) | 3.751 | 0.153 |
| Urinary stones | – | 12 (26.67%) | 21 (28.38%) | 0.041 | 0.840 |
| Cerebral vascular disease | – | 7 (15.56%) | 18 (24.32%) | 1.297 | 0.255 |
| Diabetes mellitus | – | 8 (17.78%) | 9 (12.16%) | 0.721 | 0.396 |
| Hypertension | – | 14 (34.11%) | 25 (33.78%) | 0.091 | 0.763 |
| Hypoproteinemia | – | 16 (35.56%) | 18 (24.32%) | 1.730 | 0.188 |
| Temperature, °C | 36.50 (36.30–36.60) | 36.50 (36.38–36.70) | −0.744 | 0.457 | |
| Breath rate, beats/min | – | 20.00 (20.00–21.00) | 20.00 (20.00–21.00) | −0.785 | 0.432 |
| Heart rate, beats/min | – | 89.00 (79.00–100.00) | 87.00 (75.50–100.00) | −0.858 | 0.391 |
| SBP, mmHg | – | 107.00 (98.00–115.00) | 110.00 (98.00–122.00) | −1.659 | 0.097 |
| DBP, mmHg | – | 68.00 (62.00–75.00) | 70.00 (63.00–79.25) | −0.910 | 0.363 |
| White blood cells, ×10/L | 5.80 (4.88–7.14) | 11.15 (7.67–15.31)a | 12.04 (8.96–16.69)a | 55.097 | <0.001 |
| Neutrophils, ×10/L | 3.35 (2.83–4.30) | 9.20 (6.27–13.90)a | 10.45 (6.82–14.72)a | 69.155 | <0.001 |
| Lymphocytes, ×10/L | 1.87 (1.51–2.29) | 0.81 (0.48–1.01)a | 0.72 (0.47–1.16)a | 78.375 | <0.001 |
| Monocytes, ×10/L | 0.35 (0.26–0.44) | 0.65 (0.46–0.93)a | 0.55 (0.31–0.86)a | 21.954 | <0.001 |
| Hematocrit, % | 43.30 (41.23–46.48) | 33.70 (28.65–40.35) | 35.35 (23.30–41.23)a | 41.159 | <0.001 |
| Platelets, ×10/L | 245.50 (197.50–262.50) | 171.00 (128.50–266.00)a | 158.00 (128.50–219.75)a | 20.185 | <0.001 |
| Creatinine, μmol/L | – | 67.00 (56.50–110.00) | 98.50 (62.75–177.50)b | −2.916 | 0.004 |
| Blood urea nitrogen, mmol/L | – | 6.44 (4.75–10.62) | 8.90 (5.72–15.05)b | −2.288 | 0.022 |
| Uric acid, μmol/L | – | 260.00 (197.50–360.50) | 269.50 (136.75–452.25) | −0.112 | 0.911 |
| Total bilirubin, μmol/L | – | 13.70 (8.40–21.55) | 20.20 (13.30–33.70)b | −3.507 | <0.001 |
| Partial pressure of oxygen, mmHg | – | 87.00 (73.00–96.00) | 85.50 (65.00–108.00) | −0.208 | 0.835 |
| Partial pressure of carbon dioxide, mmHg | – | 35.00 (31.00–38.50) | 36.00 (32.00–40.00) | −1.082 | 0.279 |
| Lactate, mmol/L | – | 1.80 (1.60–2.15) | 1.95 (1.38–3.50) | −0.587 | 0.557 |
| C-reactive protein, mg/L | – | 114.74 (56.99–168.49) | 109.99 (58.96–178.84) | −0.003 | 0.998 |
| Procalcitonin, ng/mL | – | 1.78 (1.06–4.83) | 3.21 (0.98–12.50)b | −3.746 | <0.001 |
| IL-1β, pg/mL | 1.51 (1.14–2.19) | 1.67 (0.77–3.07) | 3.07 (1.64–7.30),a | 23.999 | <0.001 |
| IL-23, pg/mL | 2.67 (2.32–3.59) | 3.88 (3.07–5.75)a | 7.47 (3.94–16.60),a | 54.455 | <0.001 |
| – | 1.00 (1.00–2.00) | 7.50 (4.00–10.25)b | −8.903 | <0.001 | |
| – | 11.00 (8.00–19.50) | 15.00 (8.00–25.50) | −1.698 | 0.090 | |
| – | 0 (0%) | 31 (41.90%)b | 25.492 | <0.001 | |
| ‘–’ – data not applicable; ICU – Intensive Care Unit; SBP – systolic blood pressure; DBP – diastolic blood pressure; IL-1β – interleukin 1 beta; IL-23 – interleukin 23; SOFA – sequential organ failure assessment. a Differences were considered statistically significant with b Differences were considered statistically significant with | |||||