Evaluation of the One-Hour ¹³C-Propionate Breath Test in 49 Patients from a Single Center in Japan to Detect Vitamin B₁₂ Deficiency

Yosuke Sasaki; Takahiro Sato; Tadashi Maeda; Fumiya Komatsu; Naoyuki Kawagoe; Tsunehiko Imai; Tomoyuki Shigeta; Naoyasu Kashima; Yoshihisa Urita

doi:10.12659/MSM.940238

08 May 2023: Clinical Research

Evaluation of the One-Hour C-Propionate Breath Test in 49 Patients from a Single Center in Japan to Detect Vitamin B Deficiency

Yosuke Sasaki ^ABCDEFG* , Takahiro Sato ^BDF , Tadashi Maeda ^BDFG , Fumiya Komatsu ^BCD , Naoyuki Kawagoe ^BC , Tsunehiko Imai ^ACDF , Tomoyuki Shigeta ^BF , Naoyasu Kashima ^B , Yoshihisa Urita ^ABDFG

DOI: 10.12659/MSM.940238

Med Sci Monit 2023; 29:e940238

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Background Material and Methods Results Discussion Conclusions References

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Table 3 Comparisons of RRs (%dose/h) from 1-h PBT between macrocytic and normocytic patients.

Time	Macrocytic	Normocytic	P-value

10 min	42.08±23.07	40.38±19.28	0.795
20 min	41.82±11.45	50.07±13.47	0.026^*
30 min	37.82±5.32	43.93±9.29	0.003^*
40 min	32.95±5.65	36.88±9.26	0.056
50 min	28.15±4.36	30.87±7.86	0.102
60 min	29.93±21.73	26.68±7.29	0.566

10 min	40.55±22.90	34.68±16.96	0.411
20 min	41.49±10.98	44.12±12.47	0.500
30 min	37.36±5.55	41.9±9.53	0.068
40 min	32.25±5.16	36.24±10.61	0.123
50 min	27.86±4.39	30.59±8.88	0.207
60 min	30.35±23.24	26.77±8.47	0.586

10 min	52.81±30.05	48.77±19.88	0.881
20 min	44.15±19.62	58.83±9.74	0.479
30 min	41.06±0.36	46.93±8.30	0.010^*
40 min	37.84±8.79	37.82±70	0.998
50 min	30.2±5.01	31.27±6.33	0.817
60 min	26.99±6.54	26.56±5.34	0.941
Means and standard deviations are listed. Macrocytosis was defined as mean corpuscular volume >100 fL. ^* PBT – C-propionate breath test; RR – C recovery rate.

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Evaluation of the One-Hour C-Propionate Breath Test in 49 Patients from a Single Center in Japan to Detect Vitamin B Deficiency

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