02 June 2023 : Clinical Research
Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers
Dragana Miletić1ADEF*, Marija Kraljević1ADEF, Emir Sokolović2CDE, Majana Soče3B, Marijana Milović-Kovačević4B, Simonida Bobić4B, Timur Cerić2ABDE, Stjepko Pleština3A, Semir Bešlija2AE, Inga Marijanović15ADEDOI: 10.12659/MSM.940356
Med Sci Monit 2023; 29:e940356
Table 1 Baseline characteristics of patients with metastatic HER2-positive breast cancer in 4 oncology centers in high-income and upper-middle-income countries.
| Baseline characteristics | Site | p-value | ||||
|---|---|---|---|---|---|---|
| HICZagreb (Croatia)n (%) | UMICBelgrade (Serbia)n (%) | UMICSarajevo (Bosnia and Herzegovina)n (%) | UMICMostar (Bosnia and Herzegovina)n (%) | |||
| Patients | TotalN= 170 | 42 (24.7) | 71 (41.8) | 29 (17.1) | 28 (16.5) | |
| Age at diagnosis (years) | 55.64±12.05* | 59.17±9.75* | 58.69±10.56* | 57.86±10.13* | 0.45** | |
| Menopausal status | Pre-menopause | 10 (23.8) | 7 (9.9) | 5 (17.2) | 4 (14.3) | 0.50 |
| Peri-menopause | 5 (11.9) | 6 (8.5) | 3 (10.3) | 4 (14.3) | ||
| Post-menopause | 27 (64.3) | 58 (81.7) | 21 (72.4) | 20 (71.4) | ||
| Family history of the breast cancer | Positive | 13 (31.0) | 25 (35.2) | 9 (31.0) | 4 (14.3) | 0.24 |
| Negative | 29 (69.0) | 46 (64.8) | 20 (69.0) | 24 (85.7) | ||
| Patological specimen obtained by | Surgery | 9 (12.7) | 4 (13.8) | |||
| Biopsy | 62 (87.3) | 25 (86.2) | ||||
| Patological type of breast cancer | Ductal | 41 (57.7) | ||||
| Lobular | 1 (2.4) | 4 (5.6)) | 0 (0.0) | 1 (3.6) | ||
| Inflammatory | 0 (0.0) | 0 (0.0) | ||||
| NOS | 0 (0.0) | 5 (17.9) | ||||
| Comorbidities | No | 25 (59.5) | 28 (39.4) | 14 (48.3) | 25 (59.5) | 0.13 |
| Yes | 17 (40.5) | 43 (60.6) | 15 (51.7) | 17 (40.5) | ||
| Estrogen receptor | Negative | 13 (31.0) | 24 (33.8) | 12 (41.4) | 10 (35.7) | 0.88 |
| Positive | 29 (69.0) | 47 (66.2) | 17 (58.6) | 18 (64.3) | ||
| Progesterone receptor | Negative | 15 (35.7) | 41 (57.7) | 21 (72.4) | 14 (50.0) | 0.75 |
| Positive | 27 (64.3) | 30 (42.3) | 8 (27.6) | 14 (50.0) | ||
| Ki67 (%) | No of missing values=38 | 39 (10–90)# | 32.5 (3–80)# | 37.5 (25–50)# | 30 (2–80)# | ## |
| * Mean±standard deviation; ** ANOVA testing; # median (mininum-maximum); ## Kruskal-Wallis test; cells with bolded numbers had statistically significant z-scores in post hoc chi-square testing. HIC – high-income country; UMIC – upper-middle-income country. | ||||||