05 September 2023 : Clinical Research
The Diagnostic Accuracy of N-Terminal Pro-B-Type Natriuretic Peptide and Soluble ST2 for Heart Failure in Chronic Kidney Disease Patients: A Comparative Analysis
Hongzhen Ma1BCDE, Jun Zhou2BCD, Meng Zhang1BF, Chun Shen1BF, Zhifan Jiang1BF, Tao Zhang
1ABCEFG*, Fei Gao1ACD
DOI: 10.12659/MSM.940641
Med Sci Monit 2023; 29:e940641
Table 1 Baseline characteristics.
| Variables | No-HF N=182 | HF N=238 | P value |
|---|---|---|---|
| Age, years* | 69.00 (63.00, 76.00) | 71.00 (64.00,79.00) | 0.038 |
| Male Sex, n (%)* | 92.00 (50.50) | 159.00 (66.80) | 0.001 |
| sST2, ng/mL* | 20.62 (13.99, 27.79) | 37.59 (26.25, 58.50) | <0.001 |
| NT-proBNP, pg/mL* | 329.50 (131.25, 1401.50) | 5086.00 (1589.00, 9000.00) | <0.001 |
| Heart rate, bpm* | 72.00 (65.00, 80.00) | 79.50 (70.00, 90.00) | <0.001 |
| Hypertension, n (%)* | 89.00 (48.90) | 144.00 (60.50) | 0.018 |
| Diabetes, n (%)* | 39.00 (21.40) | 75.00 (31.50) | 0.021 |
| LVEF, (%)* | 63.40 (61.90, 65.80) | 46.00 (33.00, 61.90) | <0.001 |
| LAD, mm* | 38.00 (35.00, 43.00) | 44.00 (40.00, 49.00) | <0.001 |
| LVEDD, mm* | 48.00 (45.00, 50.00) | 54.00 (47.00, 66.00) | <0.001 |
| LVESD, mm* | 31.00 (29.00, 33.00) | 42.00 (31.00, 55.00) | <0.001 |
| Hemoglobin, g/L | 127.00 (114.75, 141.00) | 128.00 (112.00, 141.00) | 0.854 |
| Albumin, g/L* | 37.10 (35.25, 39.50) | 35.30 (32.75, 37.85) | <0.001 |
| Globulin, g/L | 26.70 (24.68, 29.95) | 26.30 (23.40, 29.60) | 0.081 |
| Urea, mmol/L* | 6.84 (5.39, 9.40) | 8.73 (6.14, 13.34) | <0.001 |
| Creatinine, μmol/L* | 87.15 (62.40, 115.03) | 107.05 (79.45, 159.13) | <0.001 |
| Uric acid, μmol/L* | 368.00 (305.75, 458.25) | 464.00 (342.50, 592.00) | <0.001 |
| Potassium, mmol/L | 3.95 (3.66, 4.28) | 3.96 (3.60, 4.25) | 0.400 |
| sodium, mmol/L* | 141.00 (139.20, 143.00) | 140.30 (138.00, 142.73) | 0.017 |
| chlorine, mmol/L* | 106.00 (103.85, 108.00) | 103.95 (101.00, 106.53) | <0.001 |
| eGFR, mL/min/1.73 m* | 69.36 (49.41, 92.81) | 55.18 (34.89, 85.35) | <0.001 |
| Data are presented as the median (interquartile range) or number (percentage). * Significant difference compared to the No-HF group (P No-HF –no heart failure; HF – heart failure; sST2 – soluble ST2; NT-proBNP – N-terminal Pro-B-Type natriuretic peptide; LVEF – left ventricular ejection fraction; LAD – left atrium dimension; LVEDD – left ventricular end-diastolic dimension; LVESD – left ventricular end-systolic dimension; eGFR – estimated glomerular filtration rate. | |||