The Diagnostic Accuracy of N-Terminal Pro-B-Type Natriuretic Peptide and Soluble ST2 for Heart Failure in Chronic Kidney Disease Patients: A Comparative Analysis

05 September 2023: Clinical Research

Hongzhen Ma ^1BCDE , Jun Zhou ^2BCD , Meng Zhang ^1BF , Chun Shen ^1BF , Zhifan Jiang ^1BF , Tao Zhang ^1ABCEFG* , Fei Gao ^1ACD

DOI: 10.12659/MSM.940641

Med Sci Monit 2023; 29:e940641

Table 2 The AUCs and optimal cutoffs of sST2, NT-proBNP and 2 combinations in the Total, No-CKD, and CKD groups.

	Model	AUC	95% CI	Cutoffs	Sensitivity	Specificity	PPV	NPV
Total	sST2	0.797	0.756–0.835	28.96	0.693	0.819	0.833	0.671
	NT-proBNP	0.813	0.772–0.849	1280	0.782	0.747	0.802	0.723
	sST2+NT-proBNP	0.857	0.820–0.889	/	0.735	0.874	0.884	0.716
Non-CKD	sST2	0.788	0.726–0.842	28.71	0.713	0.794	0.774	0.736
	NT-proBNP	0.805	0.744–0.858	481	0.782	0.765	0.767	0.780
	sST2+NT-proBNP	0.861	0.805–0.905	/	0.752	0.873	0.854	0.781
CKD	sST2	0.802	0.742–0.853	30.55	0.679	0.850	0.886	0.608
	NT-proBNP	0.807	0.748–0.857	3314	0.759	0.787	0.860	0.656
	sST2+NT-proBNP	0.854	0.800–0.899	/	0.788	0.812	0.878	0.691