The Diagnostic Accuracy of N-Terminal Pro-B-Type Natriuretic Peptide and Soluble ST2 for Heart Failure in Chronic Kidney Disease Patients: A Comparative Analysis

05 September 2023 : Clinical Research

Hongzhen Ma^1BCDE, Jun Zhou^2BCD, Meng Zhang^1BF, Chun Shen^1BF, Zhifan Jiang^1BF, Tao Zhang

^1ABCEFG*, Fei Gao^1ACD

DOI: 10.12659/MSM.940641

Med Sci Monit 2023; 29:e940641

Background Material and Methods Results Discussion Conclusions References

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Table 2 The AUCs and optimal cutoffs of sST2, NT-proBNP and 2 combinations in the Total, No-CKD, and CKD groups.

	Model	AUC	95% CI	P Value	Cutoffs	Sensitivity	Specificity	PPV	NPV
Total	sST2	0.797	0.756–0.835	<0.001	28.96	0.693	0.819	0.833	0.671
	NT-proBNP	0.813	0.772–0.849	<0.001	1280	0.782	0.747	0.802	0.723
	sST2+NT-proBNP	0.857	0.820–0.889	<0.001	/	0.735	0.874	0.884	0.716
Non-CKD	sST2	0.788	0.726–0.842	<0.001	28.71	0.713	0.794	0.774	0.736
	NT-proBNP	0.805	0.744–0.858	<0.001	481	0.782	0.765	0.767	0.780
	sST2+NT-proBNP	0.861	0.805–0.905	<0.001	/	0.752	0.873	0.854	0.781
CKD	sST2	0.802	0.742–0.853	<0.001	30.55	0.679	0.850	0.886	0.608
	NT-proBNP	0.807	0.748–0.857	<0.001	3314	0.759	0.787	0.860	0.656
	sST2+NT-proBNP	0.854	0.800–0.899	<0.001	/	0.788	0.812	0.878	0.691

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