31 July 2023>: Clinical Research
Early Lactate/Albumin and Procalcitonin/Albumin Ratios as Predictors of 28-Day Mortality in ICU-Admitted Sepsis Patients: A Retrospective Cohort Study
Fuxing Li 1ABCDEF* , Zhiqiang Ye 2ABCE* , Junqi Zhu 1ABC , Shumin Gu 1BC , Suqin Peng 1BCE , Youling Fang 1BCE , Longhua Hu 1AEF* , Jianqiu Xiong 3ACEF*DOI: 10.12659/MSM.940654
Med Sci Monit 2023; 29:e940654
Table 3 Logistic regression with best subsets variable reduction.
laboratory indexes | AUC (95% CI) | Cut off-value | z-Value | Youden index J | P-Value | Sensitivity | Specificity |
---|---|---|---|---|---|---|---|
PCT (μg/L) | 0.62 (0.57–0.67) | 8.03 | 3.53 | 0.24 | 42.2% | 81.9% | |
Albumin (g/L) | 0.62 (0.56–0.67) | 24.70 | 3.25 | 0.23 | 0.001 | 34.3% | 89.1% |
Lactate (mmol/L) | 0.64 (0.58–0.69) | 2.40 | 3.89 | 0.27 | 47.1% | 79.8% | |
Creatinine (μmol/L) | 0.59 (0.54–0.65) | 99.00 | 2.66 | 0.20 | 0.008 | 60.8% | 58.8% |
PCT/ALB | 0.64 (0.58–0.69) | 0.256 | 3.95 | 0.25 | 43.1% | 81.5% | |
LA/ALB | 0.65 (0.59–0.70) | 0.079 | 4.23 | 0.29 | 53.9% | 74.4% | |
APACHE II (score) | 0.64 (0.59–0.69) | 8.0 | 4.82 | 0.28 | 84.3% | 44.1% | |
SOFA (score) | 0.83 (0.79–0.87) | 6.0 | 13.59 | 0.58 | 73.5% | 84.9% | |
PCT/ALB+LA/ALB | 0.70 (0.64–0.75) | – | 5.95 | 0.37 | 56.9% | 79.8% | |
PCT/ALB+SOFA | 0.83 (0.79–0.87) | – | 10.95 | 0.53 | 75.3% | 79.8% | |
LA/ALB+SOFA | 0.83 (0.79–0.87) | – | 12.94 | 0.60 | 77.5% | 80.6% | |
PCT/ALB+ LA/ALB+SOFA | 0.83 (0.79–0.87) | – | 13.95 | 0.61 | 80.4% | 80.7% | |
The ratios cut point in PCT/ALB+LA/ALB+SOFA variables the same as PCT/ALB, LA/ALB and SOFA alone (0.256,0.079, and 6 respectively). |