31 July 2023: Clinical Research
Early Lactate/Albumin and Procalcitonin/Albumin Ratios as Predictors of 28-Day Mortality in ICU-Admitted Sepsis Patients: A Retrospective Cohort Study
Fuxing Li 1ABCDEF* , Zhiqiang Ye 2ABCE* , Junqi Zhu 1ABC , Shumin Gu 1BC , Suqin Peng 1BCE , Youling Fang 1BCE , Longhua Hu 1AEF* , Jianqiu Xiong 3ACEF*DOI: 10.12659/MSM.940654
Med Sci Monit 2023; 29:e940654
Table 5 The comparisons of clinical characteristics between the survival and non-survival groups of septic individuals (validation cohort).
| Parameter | Total (n=75) | Survival (n=38) | Non-survival (n=37) | Z/χ2 | P-value |
|---|---|---|---|---|---|
| Patient characteristics | |||||
| Age, years | 61.00 (44.00–71.00) | 50.00 (35.00–70.50) | 63.00 (49.50–71.50) | −1.552 | 0.128 |
| Sex (male/female, n) | 50/25 | 26/12 | 24/13 | 0.107 | 0.744 |
| Constants | |||||
| Temperature (°C) | 36.80 (36.40–38.00) | 36.60 (36.35–38.05) | 36.90 (36.50–37.85) | −0.435 | 0.663 |
| Pulse rate (beats/min) | 100.00 (88.00–113.00) | 101.00 (87.50–110.75) | 99.00 (89.00–116.50) | −0.297 | 0.767 |
| Breath rate (beats/min) | 20.00 (15.00–23.00) | 20.00 (15.00–24.25) | 20.00 (15.00–22.00) | −0.359 | 0.720 |
| Systolic blood pressure (mmHg) | 124.00 (110.00–137.00) | 124.00 (110.00–137.50) | 125.00 (106.50–136.50) | −0.095 | 0.924 |
| Diastolic blood pressure (mmHg) | 70.00 (62.00–81.00) | 75.00 (64.50–85.25) | 70.00 (65.00–83.50) | −0.636 | 0.525 |
| Underlying disease (n,%) | |||||
| Hypertension | 17 (22.67) | 10 (13.33) | 7 (18.92) | 0.585 | 0.444 |
| Diabetes mellitus | 9 (12.00) | 5 (13.16) | 4 (10.81) | 0.098 | 0.754 |
| Pleural effusion | 5 (6.67) | 3 (7.89) | 2 (5.41) | 0.187 | 0.666 |
| Blood culture (n, %) | |||||
| Gram-positive rods | 20 (26.67) | 8 (21.05) | 12 (32.43) | 1.241 | 0.265 |
| Gram-negative rods | 55 (73.33) | 30 (78.95) | 25 (67.57) | ||
| Laboratory values | |||||
| White blood cells (×10/L) | 12.27 (9.66–17.97) | 14.69 (8.73–18.74) | 11.65 (10.00–16.70) | −0.784 | 0.433 |
| Neutrophils (×10/L) | 10.57 (8.49–15.13) | 12.75 (7.83–15.83) | 10.44 (8.67–14.82) | −0.848 | 0.397 |
| Lymphocytes (×10/L) | 0.71 (0.47–1.08) | 0.76 (0.43–1.12) | 0.67 (0.437–1.10) | −0.503 | 0.615 |
| HCT (%) | 35.0 (28.3–41.4) | 33.4 (28.6–39.1) | 37.5 (28.3–46.1) | −1.681 | 0.093 |
| Platelet (×10/L) | 117.00 (55.00–175.00) | 112.50 (49.75–145.25) | 121.00 (59.50–195.00) | −0.853 | 0.394 |
| Total bilirubin (μmol/L) | 18.80 (11.70–31.70) | 16.30 (12.00–31.55) | 19.30 (10.90–37.95) | −0.408 | 0.683 |
| Albumin (g/L) | 28.90 (26.70–32.70) | 31.20 (28.00–35.05) | 27.30 (25.55–30.00) | −3.132 | 0.002 |
| Creatinine (μmol/L) | 101.00 (63.00–176.00) | 95.00 (60.00–161.25) | 114.00 (71.50–221.00) | −1.325 | 0.185 |
| Blood urea nitrogen (mmol/L) | 9.39 (5.68–13.97) | 7.96 (4.86–12.27) | 10.37 (6.81–16.19) | −1.092 | 0.275 |
| Uric acid (μmol/L) | 269.00 (143.00–470.00) | 255.00 (141.50–481.75) | 282.00 (143.50–455.00) | −0.064 | 0.949 |
| Lactate (mmol/L) | 1.70 (1.10–3.20) | 1.40 (1.00–2.18) | 2.20 (1.65–4.10) | −3.395 | 0.001 |
| CRP (mg/L) | 104.29 (65.51–182.80) | 97.36 (59.37–175.38) | 121.33 (72.77–194.53) | −0.858 | 0.391 |
| PCT (μg/L) | 3.93 (0.96–13.02) | 1.46 (0.91–5.34) | 6.42 (3.96–17.43) | −3.069 | 0.002 |
| PCT/ALB | 0.131 (0.034–0.480) | 0.039 (0.029–0.182) | 0.090 (0.062–0.154) | −3.222 | 0.001 |
| Lactate/ALB | 0.063 (0.037–0.100) | 0.038 (0.032–0.077) | 0.255 (0.132–0.602) | −3.794 | |
| Disease severity | |||||
| SOFA (score) | 8.0 (5.5–10.5) | 6.0 (4.0–7.0) | 10.0 (8.0–12.0) | −5.324 | |
| Length of hospital stay (days) | 17.00 (12.00–26.00) | 19.00 (15.75–26.00) | 13.00 (6.50–27.50) | −2.847 | 0.004 |
| HCT – hematocrit; ALT – alanine aminotransferase; AST – aspartate aminotransferase; CRP – C-reactive protein; PCT – procalcitonin; ALB – albumin; SOFA – sequential organ failure assessment; APACHE – acute physiology and chronic health evaluation. | |||||