31 July 2023 : Clinical Research
Early Lactate/Albumin and Procalcitonin/Albumin Ratios as Predictors of 28-Day Mortality in ICU-Admitted Sepsis Patients: A Retrospective Cohort Study
Fuxing Li1ABCDEF, Zhiqiang Ye2ABCE, Junqi Zhu1ABC, Shumin Gu1BC, Suqin Peng1BCE, Youling Fang1BCE, Longhua Hu1AEF*, Jianqiu Xiong3ACEFDOI: 10.12659/MSM.940654
Med Sci Monit 2023; 29:e940654
Table 6 ROC analysis of laboratory indexes for predicting the prognosis of individuals with sepsis (validation cohort).
| laboratory indexes | AUC (95% CI) | z-Value | Youden index J | P-Value | Sensitivity | Specificity |
|---|---|---|---|---|---|---|
| PCT (μg/L) | 0.71 (0.59–0.81) | 3.14 | 0.60 | 0.002 | 83.8% | 76.3% |
| Albumin (g/L) | 0.71 (0.59–0.81) | 3.41 | 0.39 | <0.001 | 83.8% | 55.3% |
| Lactate (mmol/L) | 0.73 (0.61–0.82) | 3.85 | 0.36 | <0.001 | 81.1% | 55.3% |
| PCT/ALB | 0.72 (0.62–0.81) | 3.39 | 0.57 | <0.001 | 81.1% | 76.3% |
| LA/ALB | 0.76 (0.64–0.85) | 4.41 | 0.47 | <0.001 | 91.9% | 55.3% |
| SOFA (score) | 0.86 (0.76–0.93) | 8.29 | 0.69 | <0.001 | 83.8% | 76.3% |
| PCT/ALB+LA/ALB | 0.79 (0.69–0.88) | 5.57 | 0.55 | <0.001 | 75.7% | 78.9% |
| PCT/ALB+LA/ALB+SOFA | 0.91 (0.82–0.96) | 12.34 | 0.66 | <0.001 | 94.6% | 71.1% |
| The ratios cut point in PCT/ALB+LA/ALB+SOFA variables the same as PCT/ALB, LA/ALB and SOFA alone (0.256,0.079, and 6 respectively). | ||||||