Diagnostic Value of Synovial Fluid Biomarkers for Periprosthetic Joint Infection: A Prospective, Double-blind Trial

10 October 2023 : Laboratory Research

Ying Xu^123BCDE, Xueting Ma^4BCD, Haoran Guo^135CF, Hairong Tang^1BF, Jiayu Liu^1CD, Chengbin Wang^163AG, Chi Wang^73ADF*

DOI: 10.12659/MSM.940842

Med Sci Monit 2023; 29:e940842

Background Material and Methods Results Discussion Conclusions References

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Table 2 Diagnostic efficiency of synovial fluid S100A8, S100A9, and HNP1-3 for periprosthetic joint infection.

Variable	AUC	95% CI	Cut-off value	Sensitivity	Specificity	PPV	NPV
S100A8	0.964	0.929–0.998	0.104	97.4%	86.0%	86.4%	97.4%
S100A9	0.902	0.823–0.980	0.150	87.2%	88.4%	87.2%	88.4%
HNP 1-3	0.933	0.884–0.982	0.851	89.7%	83.7%	83.3%	90.0%
S100A8 – S100 calcium-binding protein A8; S100A9 – S100 calcium-binding protein A9; HNP – human neutrophil peptides; AUC – area under the curve; 95% CI – 95% confidence interval; PPV – positive predictive value; NPV – negative predictive value.

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