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10 October 2023: Lab/In Vitro Research

Diagnostic Value of Synovial Fluid Biomarkers for Periprosthetic Joint Infection: A Prospective, Double-blind Trial

Ying Xu 123BCDE , Xueting Ma 4BCD , Haoran Guo 135CF , Hairong Tang 1BF , Jiayu Liu 1CD , Chengbin Wang 123AG* , Chi Wang 13ADF*

DOI: 10.12659/MSM.940842

Med Sci Monit 2023; 29:e940842

Table 3 Effect of various influencing factors on synovial fluid S100A8, S100A9, and HNP1-3 levels.

ItemNumberS100A8Test statisticsP
Culture results of PJI patients39=−0.4260.670*
 Positive271.57 (0.48, 9.51)
 Negative121.48 (0.57, 2.56)
Infection period of PJI patients39=1.6530.438**
 Acute PJI (100.91 (0.63, 5.55)
 Delayed PJI (3~12 months)112.62 (0.94, 4.17)
 Chronic PJI (>12 months)181.42 (0.23, 4.50)
Culture results of PJI patients39=−0.6540.513*
 Positive270.74 (0.29, 4.14)
 Negative120.75 (0.21, 1.28)
Infection period of PJI patients39=4.0130.134**
 Acute PJI (100.42 (0.13, 1.55)
 Delayed PJI (3~12 months)111.11 (0.78, 4.64)
 Chronic PJI (>12 months)180.73 (0.31, 1.54)
Culture results of PJI patients39=−0.5780.563*
 Positive274.75 (1.59, 18.74)
 Negative124.05 (1.10, 10.82)
Infection period of PJI patients39=0.1220.941**
 Acute PJI (104.54 (1.96, 13.29)
 Delayed PJI (3~12 months)114.05 (0.92, 30.82)
 Chronic PJI (>12 months)185.07 (1.19, 16.97)
PJI – periprosthetic joint infection; S100A8 – S100 calcium-binding protein A8; S100A9 – S100 calcium-binding protein A9; HNP – human neutrophil peptides.
* Mann-Whitney U test;
** Kruskal-Wallis H test.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750