Diagnostic Value of Synovial Fluid Biomarkers for Periprosthetic Joint Infection: A Prospective, Double-blind Trial

10 October 2023 : Laboratory Research

Ying Xu^123BCDE, Xueting Ma^4BCD, Haoran Guo^135CF, Hairong Tang^1BF, Jiayu Liu^1CD, Chengbin Wang^163AG, Chi Wang^73ADF*

DOI: 10.12659/MSM.940842

Med Sci Monit 2023; 29:e940842

Background Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Table 3 Effect of various influencing factors on synovial fluid S100A8, S100A9, and HNP1-3 levels.

Item	Number	S100A8	Test statistics	P
Culture results of PJI patients	39		=−0.426	0.670^*
Positive	27	1.57 (0.48, 9.51)
Negative	12	1.48 (0.57, 2.56)
Infection period of PJI patients	39		=1.653	0.438^**
Acute PJI (<3 months)	10	0.91 (0.63, 5.55)
Delayed PJI (3~12 months)	11	2.62 (0.94, 4.17)
Chronic PJI (>12 months)	18	1.42 (0.23, 4.50)

Culture results of PJI patients	39		=−0.654	0.513^*
Positive	27	0.74 (0.29, 4.14)
Negative	12	0.75 (0.21, 1.28)
Infection period of PJI patients	39		=4.013	0.134^**
Acute PJI (<3 months)	10	0.42 (0.13, 1.55)
Delayed PJI (3~12 months)	11	1.11 (0.78, 4.64)
Chronic PJI (>12 months)	18	0.73 (0.31, 1.54)

Culture results of PJI patients	39		=−0.578	0.563^*
Positive	27	4.75 (1.59, 18.74)
Negative	12	4.05 (1.10, 10.82)
Infection period of PJI patients	39		=0.122	0.941^**
Acute PJI (<3 months)	10	4.54 (1.96, 13.29)
Delayed PJI (3~12 months)	11	4.05 (0.92, 30.82)
Chronic PJI (>12 months)	18	5.07 (1.19, 16.97)
PJI – periprosthetic joint infection; S100A8 – S100 calcium-binding protein A8; S100A9 – S100 calcium-binding protein A9; HNP – human neutrophil peptides. ^* Mann-Whitney U test; ^** Kruskal-Wallis H test.

Back to the Article