Diagnostic Value of Synovial Fluid Biomarkers for Periprosthetic Joint Infection: A Prospective, Double-blind Trial

10 October 2023 : Laboratory Research

Ying Xu^123BCDE, Xueting Ma^4BCD, Haoran Guo^135CF, Hairong Tang^1BF, Jiayu Liu^1CD, Chengbin Wang^163AG, Chi Wang^73ADF*

DOI: 10.12659/MSM.940842

Med Sci Monit 2023; 29:e940842

Background Material and Methods Results Discussion Conclusions References

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Table 4 The levels of common infection biomarkers in PJI and non-PJI groups.

Variables	PJI group	Non-PJI group	Test statistics	P
SF-WBC (×10/L)	14.27 (3.45, 33.92)	0.69 (0.25, 1.21)	=−6.550	<0.001^*
SF-PMN (%)	0.88 (0.72, 0.92)	0.37 (0.24, 0.57)	=−6.190	<0.001^*
ESR (mm/h)	54.00 (35.00, 82.00)	15.00 (9.00, 25.00)	=−5.468	<0.001^*
WBC (×10/L)	6.89 (6.18, 8.13)	5.82 (4.81, 7.10)	=−3.147	0.002^*
CRP (mg/dL)	2.37 (0.65, 4.12)	0.17 (0.10, 0.59)	=−5.498	<0.001^*
IL-6 (pg/mL)	14.71 (7.65, 33.32)	3.75 (1.50, 8.53)	=−5.005	<0.001^*
D (ug/mL)	1.96 (1.37, 3.78)	1.64 (0.85, 3.21)	=−1.208	0.227^*
Fib (g/L)	5.31 (4.48, 6.60)	3.20 (2.83, 4.20)	=−5.940	<0.001^*
PJI – periprosthetic joint infection; SF-WBC – synovial fluid white blood cell count; SF-PMN – percentage of polymorphonuclear neutrophil in the synovial fluid; ESR – erythrocyte sedimentation rate; WBC – whole blood white blood cell count; CRP – whole blood C-reactive protein; IL-6 – plasma interleukin-6; D-D – plasma D-dimer; Fib – plasma fibrinogen. PJI – periprosthetic joint infection; SF-WBC – synovial fluid white blood cells count; SF-PMN – percentage of polymorphonuclear neutrophil in the synovial fluid; ESR – erythrocyte sedimentation rate; WBC – whole blood white blood cell count; CRP – whole blood C-reactive protein; IL-6 – plasma interleukin-6; D-D – plasma D-dimer; Fib – plasma fibrinogen. ^* Mann-Whitney U test.

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