06 August 2023 : Clinical Research
Dynamics of Microbiome Changes in the Endometrium and Uterine Cervix during Embryo Implantation: A Comparative Analysis
Anna Bednarska-Czerwińska
ABCDEF, Emilia Morawiec ABDF, Nikola Zmarzły CDEF, Michał Szapski B, Justyna Jendrysek B, Anika PecynaB, Karolina Zapletał-PudełkoB, Weronika Małysiak B, Tomasz SirekE, Piotr OssowskiF, Aleksandra ŁachE, Dariusz BorońD, Paweł Bogdał F, Adam BernetF, Damian StrojnyF, Beniamin Oskar Grabarek AE
DOI: 10.12659/MSM.941289
Med Sci Monit 2023; 29:e941289
Table 10 Clinical profile of patients in relation to the type of microbiome.
| Normal | Light/moderate dysbiosis | Dysbiosis | P | |
|---|---|---|---|---|
| Antibiotic therapy | 82 (83.7) | 7 (7.1) | 9 (9.2) | 0.75 |
| Ofloxacin | 28 (80) | 4 (11.4) | 3 (8.6) | 0.49 |
| Cephalosporin | 50 (86.2) | 3 (5.2) | 5 (8.6) | 0.63 |
| Metronidazole | 21 (77.8) | 4 (14.8) | 2 (7.4) | 0.23 |
| Other | 23 (82.1) | 2 (7.1) | 3 (10.7) | 0.97 |
| Previous insemination | 36 (85.7) | 3 (7.1) | 3 (7.1) | 0.73 |
| Previous cryotransfer | 142 (82.1) | 15 (8.7) | 16 (9.3) | 0.43 |
| Previous embryo transfer | 33 (86.8) | 2 (5.3) | 3 (7.9) | 0.61 |
| Other previously | 2 (50) | 0 (0) | 2 (50) | 0.09 |
| Antibiotic therapy | 68 (69.4) | 6 (6.1) | 24 (24.5) | 0.30 |
| Ofloxacin | 25 (71.4) | 1 (2.9) | 9 (25.7) | 0.57 |
| Cephalosporin | 39 (67.2) | 5 (8.6) | 14 (24.1) | 0.42 |
| Metronidazole | 17 (63) | 0 (0) | 10 (37) | 0.04 |
| Other | 20 (71.4) | 2 (7.1) | 6 (21.4) | 0.91 |
| Previous insemination | 34 (81) | 1 (2.4) | 7 (16.7) | 0.29 |
| Previous cryotransfer | 127 (73.4) | 11 (6.4) | 35 (20.2) | 0.74 |
| Previous embryo transfer | 26 (68.4) | 1 (2.6) | 11 (29) | 0.23 |
| Other previously | 2 (50) | 0 (0) | 2 (50) | 0.35 |
| Antibiotic therapy | 74 (75.5) | 7 (7.1) | 17 (17.4) | 0.98 |
| Ofloxacin | 29 (82.9) | 2 (5.7) | 4 (11.4) | 0.42 |
| Cephalosporin | 42 (72.4) | 4 (6.9) | 12 (20.7) | 0.56 |
| Metronidazole | 20 (74.1) | 2 (7.4) | 5 (18.5) | 0.98 |
| Other | 19 (67.9) | 4 (14.3) | 5 (17.9) | 0.26 |
| Previous insemination | 31 (73.8) | 4 (9.5) | 7 (16.7) | 0.84 |
| Previous cryotransfer | 131 (75.7) | 13 (7.5) | 29 (16.8) | 0.65 |
| Previous embryo transfer | 27 (71.1) | 3 (7.9) | 8 (21.1) | 0.75 |
| Other previously | 1 (25) | 0 (0) | 3 (75) | 0.03 |
| N (%), non-measurable data presented in number-percentage notation for the answer “yes”. | ||||