06 August 2023 : Clinical Research
Dynamics of Microbiome Changes in the Endometrium and Uterine Cervix during Embryo Implantation: A Comparative Analysis
Anna Bednarska-Czerwińska ABCDEF, Emilia Morawiec ABDF, Nikola Zmarzły CDEF, Michał Szapski B, Justyna Jendrysek B, Anika PecynaB, Karolina Zapletał-PudełkoB, Weronika Małysiak B, Tomasz SirekE, Piotr OssowskiF, Aleksandra ŁachE, Dariusz BorońD, Paweł Bogdał F, Adam BernetF, Damian StrojnyF, Beniamin Oskar Grabarek AEDOI: 10.12659/MSM.941289
Med Sci Monit 2023; 29:e941289
Table 6 Average percentage of selected bacterial strains by type of treatment.
1st collection | 2nd collection | 3rd collection | |||||||
---|---|---|---|---|---|---|---|---|---|
Previous insemination | Yes | No | P | Yes | No | P | Yes | No | P |
group | 28.2±0 28.2 (28.2–28.2) | 14.2±13.7 10 (5.3–23.1) | – | 1±0 1 (1–1) | 35.2±34.3 21.4 (8.7–66.5) | – | 2±0.8 2 (1.5–2.6) | 23.9±28.6 11.2 (8.5–39.3) | 0.11 |
group | 27.7±0 27.7 (27.7–27.7) | 24.3±39.8 1.7 (1–70.2) | – | 32.7±43.1 17.4 (2.4–62.9) | 40.8±37.8 46.5 (4–72.9) | 0.39 | 62.9±35.1 64.9 (26.9–97.1) | 49.8±35.6 51.7 (18.4–86.2) | 0.67 |
group | 8.2±6.2 6.7 (3.7–12.7) | 25.3±13.1 26.2 (14.6–33.5) | 0.05 | 2.1±0 2.1 (2.1–2.1) | 38±27.5 32 (25.1–40.9) | – | 0±0 0 (0–0) | 27.4±28.8 25.7 (2.8–38.9) | – |
group | 47.1±39.1 43.9 (6.5–83.3) | 64.8±36.7 87.9 (34.9–96.8) | 0.23 | 45.2±38.5 40.7 (9.1–81) | 39.5±37 28.3 (4.1–81.1) | 0.74 | 45.2±35.3 40.2 (22.9–66.3) | 41.9±34.5 47.9 (5.9–71.6) | 0.68 |
group | 84.9±26.3 98.8 (79.7–99.6) | 81.9±32 98.1 (88.8–99.7) | 0.68 | 80.2±32.1 98.5 (62–99.7) | 84.9±24.7 96 (81.7–99.5) | 0.71 | 85.1±25.9 98.4 (84.6–99.6) | 87.1±21.9 97.9 (82.2–99.6) | 0.79 |
33.6±36.5 19 (12.5–54.8) | 51±36.1 54.8 (13.1–88.6) | 0.44 | 53.7±51.3 56.4 (9.4–97.9) | 57.4±38.2 60.9 (24.4–99) | 0.79 | 58.1±43.6 63.3 (21.9–94.2) | 68.7±36.6 87 (33.8–99) | 0.58 | |
group | 15.6±17.7 7.8 (5.8–25.4) | 6.1±8.6 2.9 (2.1–4.3) | 0.07 | 53.8±52.2 53.8 (16.9–90.8) | 10.2±8.8 9.1 (4.8–11.8) | 0.18 | 1.1±0 1.1 (1.1–1.1) | 11.5±9.8 11.6 (3.1–20) | – |
group | 7±9.5 3.3 (2.4–3.9) | 3.2±2.2 2.4 (1.4–5.7) | 0.57 | 2.5±1.2 2.6 (1.5–3.5) | 2.5±1.2 2.3 (1.5–3.7) | 0.80 | 4.5±5.2 2.1 (1.2–4.5) | 2.9±2.4 1.4 (1.3–3.9) | 0.94 |
group | 35.6±37.4 27.9 (4–78) | 35.5±36.2 20.3 (4.4–69.9) | 0.89 | 35.1±29.1 27.3 (7.9–46.7) | 39.1±36.5 25.7 (7.8–78.7) | 0.90 | 30±32.5 15 (7.7–50.1) | 33.3±37.5 12.2 (6–68.5) | 0.96 |
group | 14.2±11 14.2 (6.5–22) | 8.4±16.6 1.9 (1.1–2.1) | 0.24 | 13.4±17.4 3.2 (2.3–18.9) | 14.4±19.4 5.7 (3.6–12.9) | 0.66 | 9.9±14.5 4.3 (2.2–6.1) | 7.9±7.8 5.2 (1.6–10.5) | – |
group | 17±13.4 12.3 (7.7–28.2) | 0±0 0 (0–0) | – | 29.5±33.7 15.1 (2.3–66.5) | 0±0 0 (0–0) | – | 16.6±24.9 8.5 (2.6–12) | 0±0 0 (0–0) | – |
group | 25.2±32.5 14.7 (1.4–49) | 0±0 0 (0–0) | – | 38.6±37.9 32 (2.9–72.9) | 0±0 0 (0–0) | – | 52.8±34.5 64.9 (26.9–86.2) | 0±0 0 (0–0) | – |
group | 19.6±13.8 18.9 (8–30.4) | 0±0 0 (0–0) | – | 34.4±28.3 28.5 (22.4–40.9) | 0±0 0 (0–0) | – | 27.4±28.8 25.7 (2.8–38.9) | 0±0 0 (0–0) | – |
group | 60.9±37.4 78.5 (26.6–96.3) | 0±0 0 (0–0) | – | 42±36.7 34.1 (5.6–81.1) | 1±0 1 (1–1) | – | 43.6±34.2 45.2 (9–71.6) | 9.3±0 9.3 (9.3–9.3) | – |
group | 82.5±30.8 98.4 (86.5–99.7) | 96±3.1 96 (93.8–98.2) | 0.70 | 83.4±27 97 (80–99.5) | 95±6.6 95 (90.3–99.7) | 0.73 | 86.5±23 98.3 (83.7–99.6) | 90.7±12.7 90.7 (81.7–99.6) | 0.99 |
45.7±35 42 (13.1–79.8) | 99.2±0 99.2 (99.2–99.2) | – | 55±39.1 59.1 (12–97.9) | 99±0 99 (99–99) | – | 65.7±37.2 83.4 (29.4–98.3) | 99±0 99 (99–99) | – | |
group | 9.9±13 4.6 (2.1–8.7) | 0±0 0 (0–0) | – | 22.7±31 11.8 (4.8–24.3) | 0±0 0 (0–0) | – | 9.4±9.6 3.3 (2.8–19.8) | 0±0 0 (0–0) | – |
group | 4.4±5.5 2.8 (1.6–4.8) | 0±0 0 (0–0) | – | 2.5±1.2 2.3 (1.5–3.6) | 0±0 0 (0–0) | – | 3.5±3.7 1.8 (1.3–4.2) | 0±0 0 (0–0) | – |
group | 36.1±36.2 22.3 (4–72.7) | 6.2±0 6.2 (6.2–6.2) | – | 39±34.9 28.4 (7.8–72.6) | 7±0 7 (7–7) | – | 33.3±36.5 13.1 (6–63.1) | 7.1±0 7.1 (7.1–7.1) | – |
group | 9.8±14.9 2 (1.5–14.2) | 0±0 0 (0–0) | – | 14.1±18.5 5.4 (2.7–15.9) | 0±0 0 (0–0) | – | 8.6±10.2 4.7 (1.6–10.5) | 0±0 0 (0–0) | – |
group | 12.9±13.4 7.7 (3–28.2) | 23.1±15.3 23.1 (12.3–33.9) | 0.39 | 10.4±10.3 8.7 (1–21.4) | 48.6±40.5 66.5 (2.3–77.1) | 0.38 | 26.2±35.3 10.4 (1.5–66.7) | 7.1±4.7 6.6 (2.6–12) | – |
group | 25.2±32.5 14.7 (1.4–49) | 0±0 0 (0–0) | – | 35.9±35.2 32 (2.8–72.9) | 39.3±39.9 27.9 (3.5–74.2) | 0.94 | 61.3±30.9 67.5 (41.6–81) | 49±37.1 35.5 (26.9–86.2) | 0.70 |
group | 12.4±6.1 12.4 (8.1–16.7) | 21.1±14.7 22.4 (7.8–32) | 0.59 | 40.9±0 40.9 (40.9–40.9) | 33.7±29.9 25.1 (22.4–35.6) | – | 26.6±0 26.6 (26.6–26.6) | 27.4±30.4 22.5 (2.8–38.9) | – |
group | 62.3±35 78.5 (26.6–92.1) | 60.1±39.4 77.7 (18.9–97.4) | 0.78 | 43.5±39.1 35.3 (1.5–81.5) | 39.6±36.6 27.1 (4.8–77.5) | 0.93 | 55.8±31.3 50.6 (29.5–91) | 37.9±34.5 22.9 (2.2–68.8) | 0.14 |
group | 77.9±33.9 98.7 (69.2–99.8) | 83.9±29.7 98.2 (91.7–99.6) | 0.96 | 83.2±27.8 98.8 (72.2–99.7) | 83.7±26.7 96.3 (81.3–99.5) | 0.41 | 79.4±32.3 97.6 (68.4–99.7) | 88.4±19.6 98.3 (85.8–99.6) | 0.79 |
38.8±38.8 19.3 (9.9–57.8) | 50.5±35.9 49.9 (16.3–87.8) | 0.53 | 65.1±41.8 73 (30.7–99.6) | 55.2±39.7 60.9 (9–97.7) | 0.35 | 68.2±43.5 98.2 (36.5–99.3) | 66.7±36.5 83.4 (29.4–98.1) | 0.47 | |
group | 4.8±0 4.8 (4.8–4.8) | 10.5±13.7 4.3 (2.1–8.7) | – | 0±0 0 (0–0) | 22.7±31 11.8 (4.8–24.3) | – | 19.8±0 19.8 (19.8–19.8) | 6.8±8.9 3.1 (2–11.7) | – |
group | 6.7±8.7 3.1 (1.6–7) | 3.1±1.8 2.8 (1.6–3.9) | 0.70 | 3.7±0.5 3.7 (3.4–4.1) | 2.2±1.1 2 (1.4–3.6) | 0.16 | 3.6±3.5 2.1 (1–7.6) | 3.5±3.9 1.4 (1.3–3.9) | – |
group | 34.6±35.5 22.5 (8.1–55.1) | 35.7±36.6 20.3 (3.9–72.7) | 0.79 | 33.1±29.8 27.3 (7.6–46.7) | 39.5±36.3 27.8 (7.9–78) | 0.64 | 28±30.8 11.6 (2.7–62.7) | 33.8±37.8 12.4 (6.5–84.6) | 0.48 |
group | 0±0 0 (0–0) | 9.8±14.9 2 (1.5–14.2) | – | 23.5±25.5 14.6 (1.6–42.2) | 7.9±8.3 4.7 (3.4–10.5) | 0.51 | 27±12.4 27 (18.2–35.7) | 5.6±6 3.5 (1.5–7.2) | 0.06 |
group | 0±0 0 (0–0) | 17±13.4 12.3 (7.7–28.2) | – | 0±0 0 (0–0) | 29.5±33.7 15.1 (2.3–66.5) | – | 0±0 0 (0–0) | 16.6±24.9 8.5 (2.6–12) | – |
group | 0±0 0 (0–0) | 25.2±32.5 14.7 (1.4–49) | – | 0±0 0 (0–0) | 38.6±37.9 32 (2.9–72.9) | – | 68±0 68 (68–68) | 51.6±35.7 50.2 (22.7–88.3) | – |
group | 0±0 0 (0–0) | 19.6±13.8 18.9 (8–30.4) | – | 0±0 0 (0–0) | 34.4±28.3 28.5 (22.4–40.9) | – | 0±0 0 (0–0) | 27.4±28.8 25.7 (2.8–38.9) | – |
group | 98.5±0 98.5 (98.5–98.5) | 60±37.4 75.3 (23.4–96) | – | 92.4±0 92.4 (92.4–92.4) | 39.3±36.3 30.6 (4.1–74) | – | 10.7±0 10.7 (10.7–10.7) | 43.6±34.2 45.2 (8.3–71.6) | – |
group | 98.9±0 98.9 (98.9–98.9) | 82.4±30.7 98.1 (86.5–99.7) | – | 97.3±0 97.3 (97.3–97.3) | 83.4±27 97 (80–99.5) | – | 92.3±0 92.3 (92.3–92.3) | 86.4±23 98.3 (82.6–99.6) | – |
77.6±19.7 77.6 (63.7–91.5) | 45.2±36.2 39 (13.1–79.8) | 0.25 | 81.5±24.7 81.5 (64.1–99) | 54.6±40 57.3 (9–98.2) | 0.45 | 64.4±49.9 87 (7.2–99) | 67.4±36.4 84.9 (33.8–98.3) | 0.90 | |
group | 0±0 0 (0–0) | 9.9±13 4.6 (2.1–8.7) | – | 0±0 0 (0–0) | 22.7±31 11.8 (4.8–24.3) | – | 0±0 0 (0–0) | 9.4±9.6 3.3 (2.8–19.8) | – |
group | 0±0 0 (0–0) | 4.4±5.5 2.8 (1.6–4.8) | – | 3.7±0 3.7 (3.7–3.7) | 2.4±1.2 2.1 (1.4–3.6) | – | 0±0 0 (0–0) | 3.5±3.7 1.8 (1.3–4.2) | – |
group | 34.9±0 34.9 (34.9–34.9) | 35.5±36.4 20.3 (4–72.7) | – | 35.3±0 35.3 (35.3–35.3) | 38.3±35.2 26.6 (7.8–72.6) | – | 12.4±0 12.4 (12.4–12.4) | 33.2±36.6 13.1 (6–63.1) | – |
group | 1.9±0 1.9 (1.9–1.9) | 11±15.7 2.1 (1.1–22) | – | 0±0 0 (0–0) | 14.1±18.5 5.4 (2.7–15.9) | – | 0±0 0 (0–0) | 8.6±10.2 4.7 (1.6–10.5) | – |
X±SD, Me (Q1–Q3) – measurable data presented as mean and standard deviation, median (quartiles 1 and 3); N (%) – non-measurable data presented in number-percentage notation. |