Time-Dependent Factors Influencing Cardiocerebral Vascular Events in Chronic Hemodialysis Patients: Insights from a Longitudinal Study

Haowen Zhong; Mengbi Zhang; Xiaoyan Su; Yuqin Qing; Yanhong Lai; Jianhua Chen; Linqing Chen; Aiqin Cao; Xun Liu; Shaohong Li

doi:10.12659/MSM.941553

17 October 2023 : Clinical Research

Time-Dependent Factors Influencing Cardiocerebral Vascular Events in Chronic Hemodialysis Patients: Insights from a Longitudinal Study

Haowen Zhong^1CDE, Mengbi Zhang^2CD, Xiaoyan Su^2DG, Yuqin Qing^3C, Yanhong Lai^2B, Jianhua Chen^2F, Linqing Chen^2BF, Aiqin Cao^2F, Xun Liu^4AG*, Shaohong Li^5AG

DOI: 10.12659/MSM.941553

Med Sci Monit 2023; 29:e941553

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Table 2 Time-dependent Cox regression revealed the time-dependent influencing factors of cardiocerebral vascular events (CVCs) on hemodialysis (HD) patients.

Indexes	Univariate			Multivariate
Indexes	RR	95% CI	P	RR	95% CI	P
HGB (g/L)	0.981	0.969–0.992	0.001
ALB (g/L)	0.940	0.898–0.985	0.009
WBC (G/L)	1.102	1.051–1.156	0.001
CRP (mg/L)	1.008	1.005–1.011	0.001	1.009	1.004–1.013	0.001
BFR (mL/min)	0.989	0.981–0.996	0.005	0.991	0.984–0.999	0.028
Blood flow rate (BFR) during HD was the independent time-dependent protective factor of CVCs on HD patients. C-reactive protein (CRP) was the independent time-dependent risk factor of CVCs on HD patients. CVCs – cardiocerebral vascular events; HD – hemodialysis; BFR – blood flow rate; HGB – hemoglobin; WBC – white blood cells; CRP – C-reactive protein; ALB – serum albumin.

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Time-Dependent Factors Influencing Cardiocerebral Vascular Events in Chronic Hemodialysis Patients: Insights from a Longitudinal Study

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