06 March 2024 : Clinical Research
Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies
Ewelina Hallmann
1ABDEFG*, Aleksander Masny 1AD, Anna Poznańska 2CD, Francisco Pozo 34A, Inmaculada Casas34A, Lidia Bernadeta Brydak 1AD
DOI: 10.12659/MSM.942125
Med Sci Monit 2024; 30:e942125
Table 2 Summary of results related to the detected mutations in the influenza viruses tested.
| Parameter | A/H1N1/pdm09 | A/H3N2/ | B | Statistical significance of differences in selected parameters |
|---|---|---|---|---|
| Number of samples | 36 | 100 | 57 | – |
| % of samples with mutations | 86% | 89% | 72% | – |
| Median number of mutations in the sample | 19 | 4 | 4 | For A/H1N1/pdm09 significantly more than for each of the others (p<0.001), no differences between A/H3N2/ and B (p>0.05) |
| % of samples in which mutations carrying drug resistance were detected | 50% | 22% | 47% | For A/H3N2/ significantly less than for A/H1N1/pdm09 (p=0.002) and for B (p<0.001), no differences between A/H1N1/pdm09 and B (p>0.05) |
| Number of mutations carrying drug resistance/1 sample tested | 1.1 | 0.3 | 1.7 | For A/H3N2/ significantly less than for A/H1N1/pdm09 (p=0.004) and for B (p<0.001), no differences between A/H1N1/pdm09 and B (p>0.05) |
| % of mutations carrying drug resistance | 5.4% | 6.3% | 19.1% | For B significantly more than for the others (p<0.001), no differences between A/H1N1/pdm09 and A/H3N2/ (p>0.05) |