06 March 2024: Clinical Research
Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies
Ewelina Hallmann 1ABDEFG* , Aleksander Masny 1AD , Anna Poznańska 2CD , Francisco Pozo 34A , Inmaculada Casas 34A , Lidia Bernadeta Brydak 1ADDOI: 10.12659/MSM.942125
Med Sci Monit 2024; 30:e942125
Table 3 Percentage distribution of other properties at the site of detected mutations in influenza viruses in Poland.
| Properties at the mutation site | Influenza virus subtype A/H1N1/pdm09 | Influenza virus subtype A/H3N2/ | Influenza virus type B |
|---|---|---|---|
| Viral oligomerization interface | 34% | 36% | 31% |
| Drug binding site | 3% | 4% | 8% |
| Ligand binding site | 34% | 43% | 41% |
| Antibody binding site | 11% | 7% | 13% |
| Host protein binding site | 2% | 2% | 0.3% |
| Point mutation/escape mutation | 8% | 4% | 4% |
| Virulence | 0.5% | 0.2% | 0.3% |
| N-glycosylation | 6% | 4% | 2% |