21 November 2023>: Review Articles
Circadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic Opportunities
Jiayue Lin 12EF* , Haoming Kuang 1F* , Jiahao Jiang 3BF , Hui Zhou 4A , Li Peng 2B , Xu Yan 2AE* , Jianjun Kuang 5EF*DOI: 10.12659/MSM.942215
Med Sci Monit 2023; 29:e942215
Table 1 Core circadian “clock gene” products and other clock-relevant protein families.
Abbreviation | Full name | Common alternative names |
---|---|---|
CLOCK | Circadian locomotor output cycles kaput | bHLHe8 |
NPAS2 | Neuronal PAS domain protein 2 | Mop4, bHLHe9 |
BMAL1 | Brain and muscle ARNT-like 1 | Arntl, bHLHe5, Mop3, Arnt3 |
BMAL2 | Brain and muscle ARNT-like 2 | Arnl2, bHLHe6, Mop9, Clif |
DEC1 | Differentiated embryonic chondrocyte-expressed gene 1 | Bhlhe40, Sharp-2, Stra13 |
DEC2 | Differentiated embryonic chondrocyte-expressed gene 2 | Bhlhe41, Sharp-1 |
PER1 | Period 1 (period circadian protein homolog 1) | |
PER2 | Period 2 (period circadian protein homolog 2) | |
PER3 | Period 3 (period circadian protein homolog 3) | |
CRY1 | Cryptochrome 1 (photolyase-like) | |
CRY2 | Cryptochrome 2 (photolyase-like) | |
REV-ERBa | Nuclear receptor subfamily 1, group D, member 1 | Nrld1, Rev-erb-alpha |
REV-ERBb | Nuclear receptor subfamily 1, group D, member 2 | Nrld2, Rev-erb-beta, RVR |
RORa | RAR-related orphan receptor alpha (ROR-alpha) | Nrlf1, Rora, ROR1 |
RORb | RAR-related orphan receptor beta (ROR-beta) | Nrlf2, Rorb, RZR-beta |
RORy | RAR-related orphan receptor gamma (ROR-gamma) | Nrlf3, Rorc, Thor, TOR |
CK1 | Casein kinase 1 delta | Csnk1d, CK1d |
CK1 | Casein kinase 1 epsilon | Csnkle, CK1e, tau mutation |
CK1 | Casein kinase 1 alpha | Csnk1a1 |
CK2 | Casein kinase 2 alpha 1 | Csnk2a1 |
FBXL3 | F-box and leucine-rich repeat protein 3 | SCF F-box like 3 |
FBXL21 | F-box and leucine-rich repeat protein 21 | SCFFbx121, FBXL3B |
b-TrCP1 | Beta-transducin repeat containing protein | Fbw 1a; FWD1 |
b-TrCP2 | Beta-transducin repeat containing protein 2 | Fbxw11; BTRCP |
DBP | D site albumin promoter binding protein | D-box binding protein |
HLF | Hepatic leukemia factor | |
TEF | Thyrotroph embryonic factor | |
R4BP4 | E4 promoter-binding protein 4 | Nuclear factor IL3 (NFIL3) |