Association of Ischemia-Modified Albumin (IMA) in Saliva, Serum, and Urine with Diagnosis of Chronic Kidney Disease (CKD) in Children: A Case-Control Study

Julita Szulimowska; Anna Zalewska; Katarzyna Taranta-Janusz; Daria Trocka; Małgorzata Żendzian-Piotrowska; Ryszard Tomasiuk; Mateusz Maciejczyk

doi:10.12659/MSM.942230

14 December 2023: Clinical Research

Association of Ischemia-Modified Albumin (IMA) in Saliva, Serum, and Urine with Diagnosis of Chronic Kidney Disease (CKD) in Children: A Case-Control Study

Julita Szulimowska ^1ABCDEF , Anna Zalewska ^1ACD , Katarzyna Taranta-Janusz ^2ABD , Daria Trocka ^3C , Małgorzata Żendzian-Piotrowska ^4C , Ryszard Tomasiuk ^5C , Mateusz Maciejczyk ^4ACDEFG*

DOI: 10.12659/MSM.942230

Med Sci Monit 2023; 29:e942230

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Table 3 Correlations with clinical parameters in children with chronic kidney disease (CKD).

	NWS IMA		SWS IMA		Serum IMA		Urine IMA
	r	P	r	p	r	p	r	p
Age	0.318	0.13	0.376	0.07	0.016	0.944	−0.144	0.522
eGFR	−0.798		−0.098	0.648	0.256	0.262	0.094	0.678
CKD stage	0.814		0.027	0.901	−0.262	0.252	−0.131	0.561
Serum Cr	0.711		0.221	0.299	−0.341	0.131	−0.206	0.357
Serum urea	0.739		−0.036	0.867	−0.326	0.15	−0.203	0.365
Albuminuria	0.456	0.089	−0.043	1	−0.206	0.499	−0.326	0.277
Proteinuria	0.01	0.969	−0.264	0.274	−0.065	0.812	0.277	0.282
Hgb	−0.186	0.395	0.066	0.765	0.023	0.922	−0.021	0.929
Hct	−0.165	0.442	0.011	0.96	−0.063	0.786	0.05	0.824
Fe	0.308	0.143	−0.153	0.475	0.083	0.722	−0.131	0.563
Ferritin	0.051	0.822	0.002	0.994	−0.235	0.333	−0.053	0.823
UIBC	−0.025	0.915	−0.026	0.911	0.231	0.356	−0.061	0.803
ALP	0.203	0.365	0.181	0.419	0.121	0.622	0.085	0.722
PTH	0.491		0.089	0.686	−0.045	0.85	−0.019	0.935
Ca	0.269	0.204	−0.194	0.364	0.008	0.973	−0.501	0.018
Vit. D	−0.194	0.374	0.059	0.788	−0.063	0.791	−0.402	0.07
SBP	0.196	0.358	0.015	0.944	−0.448		−0.423
DBP	0.16	0.454	0.011	0.958	−0.501		−0.54
IMA NWS	1		0.066	0.759	−0.377	0.092	−0.307	0.165
IMA SWS	0.066	0.759	1		−0.145	0.529	0.066	0.77
IMA serum	−0.377	0.092	−0.145	0.529	1		0.396	0.093
IMA urine	−0.307	0.165	0.066	0.77	0.396	0.093	1
Spearman;s rank correlation coefficient was used. ALP – alkaline phosphatase; Ca – calcium ions; DBP – diastolic blood pressure; eGFR – estimated glomerular filtration rate determined with the Schwartz formula; Fe – serum iron levels; Hgb – hemoglobin level; Hct – hematocrit; NWS – non-stimulated whole saliva; SWS – stimulated whole saliva; PTH – parathyroid hormone; SBP – systolic blood pressure; sCr – serum creatinine; UA – uric acid; UIBC – unsaturated iron-binding capacity; Vit. D – vitamin D.

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Association of Ischemia-Modified Albumin (IMA) in Saliva, Serum, and Urine with Diagnosis of Chronic Kidney Disease (CKD) in Children: A Case-Control Study

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