14 December 2023: Clinical Research
Association of Ischemia-Modified Albumin (IMA) in Saliva, Serum, and Urine with Diagnosis of Chronic Kidney Disease (CKD) in Children: A Case-Control Study
Julita Szulimowska 1ABCDEF , Anna Zalewska 1ACD , Katarzyna Taranta-Janusz 2ABD , Daria Trocka 3C , Małgorzata Żendzian-Piotrowska 4C , Ryszard Tomasiuk 5C , Mateusz Maciejczyk 4ACDEFG*DOI: 10.12659/MSM.942230
Med Sci Monit 2023; 29:e942230
Table 4 Receiver operating characteristic (ROC) analysis of the content of ischemia-modified albumin (IMA) in non-stimulated whole saliva of children with different stages of CKD (stages 1–5).
| AUC | 95% CI | P-value | Cut-off | Sensitivity% | 95% CI | Specificity% | 95% CI | |
|---|---|---|---|---|---|---|---|---|
| Stage 1 vs Control | 0.60 | 0.3903 to 0.8121 | 0.4219 | 57.14 | 25.05% to 84.18% | 50.00 | 31.43% to 68.57% | |
| Stage 2 vs Control | 0.51 | 0.2931 to 0.7346 | 0.9385 | >0.2977 | 66.67 | 11.85% to 98.29% | 45.83 | 27.89% to 64.93% |
| Stage 3 vs Control | 1.00 | 1.000 to 1.000 | 0.0209 | >1.076 | 100.00 | 17.77% to 100.0% | 100.00 | 86.20% to 100.0% |
| Stage 4 vs Control | 0.83 | 0.6120 to 1.000 | 0.0148 | >0.6764 | 66.67 | 30.00% to 94.08% | 75.00 | 55.10% to 88.00% |
| Stage 5 vs Control | 1.00 | 1.000 to 1.000 | 0.0002 | >1.155 | 100.00 | 60.97% to 100.0% | 100.00 | 86.20% to 100.0% |
| Stages 1–3 vs Control | 0.53 | 0.3264 to 0.7291 | 0.7883 | >0.3223 | 50.00 | 25.38% to 74.62% | 50.00 | 31.43% to 68.57% |
| Stages 4–5 vs Control | 0.91 | 0.7950 to 1.000 | >0.7137 | 83.33 | 55.20% to 97.04% | 87.50 | 69.00% to 95.66% | |
| Stages 4–5 vs Stages 1–3 | 0.87 | 0.7140 to 1.000 | 0.0022 | >0.8135 | 83.33 | 55.20% to 97.04% | 83.33 | 55.20% to 97.04% |