11 January 2024: Clinical Research
Predicting Acute Kidney Injury in Trauma Patients: Biomarkers as Early Indicators
Michal Frelich 12ABCDEFG , Vojtěch Vodička 1BF , Ondřej Jor 12BD , Filip Burša 12BDF , Peter Sklienka 12ABCE*DOI: 10.12659/MSM.942271
Med Sci Monit 2024; 30:e942271
Table 2 Levels of biomarkers at 2 time points: admission and after 24 h.
| Characteristic | Non-AKIn=73 (74.5%) | AKIn=25 (25.5%) | P value |
|---|---|---|---|
| HMGB-1 (μg/L) | 48.3 (98.4) | 113.0 (209.4) | 0.006 |
| NGAL (μg/L) | 150.2 (349.9) | 181.4 (152.2) | 0.004 |
| CK (μkat/L) | 14.5 (9.2) | 13.7 (7.9) | 0.916 |
| Creatinine (μmol/L) | 83.1 (20.8) | 118.8 (32.2) | |
| Interleukin 6 (ng/L) | 279.6 (328.2) | 811.6 (1457.8) | 0.039 |
| Myoglobin (μg/L) | 2734.4 (2214.5) | 4182.3 (2477.1) | 0.008 |
| NGAL 24 h (μg/L) | 87.3 (45.2) | 196.3 (90.7) | |
| CK 24 h (μkat/L) | 52.2 (43.6) | 78.8 (52.4) | 0.018 |
| Creatinine 24 h (μmol/L) | 76.4 (18.7) | 148.6 (33.2) | |
| Interleukin 6 24 h | 315.1 (496.1) | 621.7 (1168.2) | 0.241 |
| Myoglobin 24 h (μg/L) | 1473.2 (1899.8) | 6019.7 (6213.7) | |
| HMGB-1 – high mobility group box-1; NGAL – neutrophil gelatinase-associated lipocalin; CK – creatine kinase. | |||