Predicting Acute Kidney Injury in Trauma Patients: Biomarkers as Early Indicators

11 January 2024: Clinical Research

Michal Frelich ^12ABCDEFG , Vojtěch Vodička ^1BF , Ondřej Jor ^12BD , Filip Burša ^12BDF , Peter Sklienka ^12ABCE*

DOI: 10.12659/MSM.942271

Med Sci Monit 2024; 30:e942271

Table 3 Performance of admission biomarkers in predicting acute kidney injury (AKI).

	AUC	Standard error AUC	P Value	95% CI	Cut-off value	Sensitivity (%)	Specificity (%)

HMGB-1 μg/L	0.685	0.066	0.005	0.556–0.815	59.7	48	88
NGAL μg/L	0.694	0.056	0.001	0.584–0.804	132.6	68	69
Creatinine μmol/L	0.832	0.049	0.000	0.736–0.927	99	76	82
CK μkat/L	0.493	0.069	0.918	0.357–0.629	12.9	72	39
Myoglobin μg/L	0.679	0.066	0.007	0.550–0.809	3009.9	72	66

NGAL μg/L	0.869	0.047	0.000	0.778–0.960	126.5	80	88
Creatinine μmol/L	0.971	0.018	0.000	0.935–1.007	111	92	99
CK μkat/L	0.659	0.063	0.011	0.536–0.783	38.6	80	48
Myoglobin μg/L	0.809	0.056	0.000	0.699–0.920	2654	64	90
AUC – area under the receiver operating characteristic curve; CI – confidence interval; HMGB-1 – high mobility group box-1; NGAL – neutrophil gelatinase-associated lipocalin; CK – creatine kinase.