01 February 2024 : Animal Research
Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mechanical Allodynia in a Rat Model of Mild Traumatic Brain Injury
Jiyoun Lee
1BCDEF, Soeun Jeon 2ABCDE, Nara Kim 3BE, Sangmin Choi 3BE, Wangseok Do 3ABC, Jae-Rin Kim 4BCE, Eunsoo Kim 34AC, Jeong-Min Hong 34AC, Jiseok Baik 34ACDEFG*
DOI: 10.12659/MSM.942574
Med Sci Monit 2024; 30:e942574
Table 2 Changes in body weight (g) with time.
| Group S | Group T | Group K | P value | |
|---|---|---|---|---|
| Preoperative | 216.0 (210.0, 224.9) []15 | 220.0 (216.8, 223.8) []15 | 222.5 (212.9, 232.3) []15 | 0.432 |
| POD 1 | 206.5 (195.6, 212.5) []15 | 212.5 (204.1, 216.1) []15 | 206.0 (201.3, 222.5) []12 | 0.400 |
| POD 7 | 248.0 (238.8, 259.5) []15 | 253.5 (249.1, 262.8) []15 | 254.5 (243.5, 271.0) []12 | 0.298 |
| POD 14 | 292.0 (282.1, 305.0) []15 | 293.8 (289.0, 299.5) []14 | 298.0 (296.3, 312.9) []12 | 0.069 |
| Data are presented as median with 1 and 3 quartiles [number]. The Conover tests were performed for post hoc multiple comparisons as appropriate. Group S – sham surgery; group T – traumatic brain injury; group K – intrathecal ketamine group; POD – postoperative day. | ||||