01 February 2024: Animal Study
Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mechanical Allodynia in a Rat Model of Mild Traumatic Brain Injury
Jiyoun Lee 1BCDEF* , Soeun Jeon 2ABCDE* , Nara Kim 3BE , Sangmin Choi 3BE , Wangseok Do 3ABC , Jae-Rin Kim 4BCE , Eunsoo Kim 34AC , Jeong-Min Hong 34AC , Jiseok Baik 34ACDEFG*DOI: 10.12659/MSM.942574
Med Sci Monit 2024; 30:e942574
Table 3 Changes in concentration of brain-derived neurotrophic factor (pg/ml) in cerebrospinal fluid.
| Group S | Group T | Group K | P value | |
|---|---|---|---|---|
| POD 1 | 7.3 (6.0, 8.8) []6 | 11.0 (10.6, 12.3) []7 | 18.9 (16.1, 23.0) [],4 | 0.006 |
| POD 7 | 12.5 (5.9, 17.8) []8 | 9.5 (5.9, 14.6) []8 | 11.2 (10.5, 14.0) []5 | 0.686 |
| POD 14 | 7.1 (2.7, 9.4) []7 | 9.8 (6.5, 14.7) []8 | 9.0 (5.9, 10.1) []4 | 0.437 |
| Data are presented as median with 1 and 3 quartiles [number]. The Conover tests were performed for post hoc multiple comparisons as appropriate. Group S – sham surgery; group T – traumatic brain injury; group K – intrathecal ketamine group; POD – postoperative day. * # | ||||