15 February 2024: Clinical Research
The Impact of Serum Uric Acid Levels on Hypertensive Disorders of Pregnancy in Advanced Maternal Age Women: A Retrospective Study from a Single Center in China
Li Luo 12ADEFG* , Sulan Huang 2ABCEF** , Zhijie Zhuang 3BE* , Yeping Mo 4BE* , Ning Guo 2CE , Liangqing Ge 12E*DOI: 10.12659/MSM.942629
Med Sci Monit 2024; 30:e942629
Table 1 Baseline clinical characteristics before and after propensity score matching.
| Characteristic | Before PSM | After PSM | ||||||
|---|---|---|---|---|---|---|---|---|
| NUA (N=674) | HUA (N=106) | SMD | P values | NUA (N=168) | HUA (N=84) | SMD | P values | |
| Age (years) | 37.00 (35.00–39.00) | 37.00 (35.00–39.00) | 0 | 0.933 | 38.00 (36.00–40.25) | 37.50 (35.00–39.00) | 0.20 | 0.130 |
| Gravidity (num) | 3.00 (2.00–5.00) | 3.00 (2.00–5.00) | 0.08 | 0.529 | 3.50 (3.00–5.00) | 3.00 (2.00–5.00) | 0.10 | 0.391 |
| Parity, (num) | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | 0.10 | 0.338 | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | 0.12 | 0.476 |
| BMI (kg/m) | 27.98 (25.76–30.04) | 28.04 (26.16–30.49) | 0.08 | 0.311 | 27.71 (25.66–29.59) | 27.89 (26.04–30.04) | 0.14 | 0.273 |
| RDW (%) | 14.00 (13.30–14.80) | 14.30 (13.30–15.20) | 0.19 | 0.044 | 14.20 (13.20–15.10) | 14.30 (13.30–15.20) | 0.12 | 0.359 |
| WBC (10/L) | 8.83 (7.26–10.49) | 8.81 (7.11–11.05) | 0.01 | 0.922 | 8.93 (7.20–11.16) | 8.83 (6.97–11.13) | 0.05 | 0.965 |
| RBC (10/L) | 3.86 (3.55–4.14) | 3.79 (3.34–4.23) | 0.08 | 0.846 | 3.90 (3.62–4.19) | 3.79 (3.45–4.23) | 0.12 | 0.173 |
| Hb (g/L) | 117.00 (108.00–126.00) | 116.00 (104.00–129.00) | 0.01 | 0.745 | 117.50 (109.75–127.00) | 116.50 (104.00–128.00) | 0.19 | 0.291 |
| Platelets (10/L) | 186.00 (155.00–222.00) | 169.00 (139.00–211.00) | 0.28 | 0.002 | 185.50 (154.75–230.00) | 169.50 (146.00–211.00) | 0.16 | 0.009 |
| ALB (g/L) | 35.30 (33.70–37.40) | 34.30 (31.30–37.20) | 0.22 | 0.014 | 35.45 (33.98–37.90) | 34.45 (31.30–37.00) | 0.18 | 0.016 |
| ALT (U/L) | 14.00 (10.00–20.00) | 16.00 (11.00–28.00) | 0.33 | 0.002 | 13.00 (10.00–22.00) | 14.50 (11.00–35.00) | 0.11 | 0.109 |
| AST (U/L) | 19.00 (16.00–25.00) | 26.00 (21.00–31.00) | 0.39 | 19.00 (16.00–27.00) | 24.00 (20.00–29.00) | 0.20 | ||
| BUN (mmol/L) | 3.25 (2.74–4.03) | 4.23 (3.58–5.30) | 0.55 | 3.08 (2.58–3.64) | 4.04 (3.52–4.72) | 0.14 | ||
| Creatinine (umol/L) | 46.00 (40.00–52.00) | 59.00 (52.00–69.00) | 1.17 | 38.50 (35.00–53.00) | 55.00 (49.00–65.00) | 0.11 | ||
| Potassium (mmol/L) | 3.93 (3.78–4.10) | 4.06 (3.85–4.35) | 0.52 | 3.91 (3.67–4.06) | 4.08 (3.93–4.34) | 0.09 | ||
| TG (mmol/L) | 3.82 (3.82–3.82) | 3.82 (3.47–4.78) | 0.29 | 0.004 | 3.82 (3.82–3.82) | 3.82 (3.47–4.67) | 0.11 | 0.078 |
| TC (mmol/L) | 6.08 (6.08–6.08) | 6.08 (5.84–6.80) | 0.21 | 0.024 | 6.08 (6.08–6.08) | 6.08 (5.87–6.80) | 0.16 | 0.011 |
| HDL (mmol/L) | 1.83 (1.83–1.83) | 1.83 (1.66–1.96) | 0.10 | 0.208 | 1.83 (1.83–1.83) | 1.83 (1.83–1.96) | 0.01 | 0.001 |
| LDL (mmol/L) | 3.03 (3.03–3.03) | 3.03 (2.74–3.68) | 0.20 | 0.091 | 3.03 (3.03–3.03) | 3.03 (2.95–3.68) | 0.05 | 0.025 |
| Blood sugar (mmol/L) | 4.93 (4.31–5.73) | 4.98 (4.23–6.06) | 0.25 | 0.345 | 4.99 (4.40–6.08) | 4.99 (4.09–5.95) | 0.16 | 0.921 |
| SUA (umol/L) | 304.00 (256.00–346.00) | 467.00 (439.00–519.00) | 314 | 291.50 (232.75–323.25) | 459.50 (435.00–507.00) | 0.11 | ||
| ESR (mm/h) | 37.00(37.00–37.00) | 37.00(36.00–37.00) | 0.09 | 0.081 | 37.00 (37.00–37.00) | 37.00 (36.00–37.00) | 0.15 | 0.110 |
| SBP (mmHg) | 124.00 (112.00–138.00) | 136.00 (125.00–155.00) | 0.59 | 124.00 (109.75–141.25) | 132.50 (123.00–155.00) | 0.15 | ||
| DBP (mmHg) | 79.00 (70.00–89.00) | 89.00 (79.00–97.00) | 0.65 | 75.50 (68.50–87.00) | 86.50 (79.00–96.00) | 0.16 | ||
| Heart rate (beats/min) | 91.00 (84.00–100.00) | 89.00 (85.00–98.00) | 11 | 0.393 | 91.00 (82.75–101.00) | 89.50 (85.00–98.00) | 0.11 | 0.692 |
| Gestational week (weeks) | 18.20 (15.50–19.00) | 17.40 (14.60–18.50) | 0.06 | 0.013 | 17.50 (14.30–18.50) | 17.40 (14.60–18.50) | 0.19 | 0.600 |
| GDM, n (%) | 0.21 | 0.038 | 0.06 | 0.052 | ||||
| No | 486 (72.11%) | 66 (62.26%) | 124 (73.81%) | 52 (61.90%) | ||||
| Yes | 188 (27.89%) | 40 (37.74%) | 44 (26.19%) | 32 (38.10%) | ||||
| Urine protein, n (%) | 0.30 | 0.005 | 0.17 | 0.212 | ||||
| No | 366 (54.30%) | 42 (39.62%) | 90 (53.57%) | 38 (45.24%) | ||||
| Yes | 308 (45.70%) | 64 (60.38%) | 78 (46.43%) | 46 (54.76%) | ||||
| HDP, n (%) | 0.77 | 0.06 | ||||||
| No | 458 (67.95%) | 34 (32.08%) | 112 (66.67%) | 32 (38.10%) | ||||
| Gestational hypertension | 92 (13.65%) | 32 (30.19%) | 28 (16.67%) | 24 (28.57%) | ||||
| Preeclampsia or eclampsia | 124 (18.40%) | 40 (37.74%) | 28 (16.67%) | 28 (33.33%) | ||||
| Data are expressed as median (Q1–Q3) or number (%). SMD – standardized mean difference; BMI– body mass index; WBC – white blood cell; RBC – red blood cell; Hb – haemoglobin; RDW – red blood cell distribution width; ALB – albumin; ALT – alanine transaminase; AST – aspartate transaminase; BUN – urea nitrogen; TC – total cholesterol; TG – triglyceride; HD – high-density lipoprotein; LDL – low density lipoprotein; ESR – erythrocyte sedimentation rate; SBP – systolic blood pressure; DBP – diastolic blood pressure; GDM – gestational diabetes; HDP – hypertensive disorders of pregnancy. | ||||||||