15 February 2024: Clinical Research
The Impact of Serum Uric Acid Levels on Hypertensive Disorders of Pregnancy in Advanced Maternal Age Women: A Retrospective Study from a Single Center in China
Li Luo 12ADEFG* , Sulan Huang 2ABCEF** , Zhijie Zhuang 3BE* , Yeping Mo 4BE* , Ning Guo 2CE , Liangqing Ge 12E*DOI: 10.12659/MSM.942629
Med Sci Monit 2024; 30:e942629
Table 4 Adjusted odds ratios for the prevalence of HDP according to the presence of HUA in the PS-matched cohort.
| Exposure | Non-adjusted | Adjust I | Adjust II | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| SUA group | ||||||
| Normal SUA | 1.0 | 1.0 | 1.0 | |||
| High SUA | 3.25 (1.88, 5.60) | 3.31 (1.85, 5.91) | 2.88 (1.44, 5.75) | 0.0027 | ||
| SUA as continuous variable (mmol/L) | 1.01 (1.01, 1.01) | 1.01 (1.01, 1.01) | 1.01 (1.00, 1.01) | |||
| SUA per SD increase | 2.30 (1.73, 3.07) | 2.37 (1.72, 3.25) | 2.35 (1.57, 3.50) | |||
| Tertile of SUA | ||||||
| Tertile 1 (139–290) | 1.0 | 1.0 | 1.0 | |||
| Tertile 2 (293–413) | 3.03 (1.54, 5.95) | 0.0013 | 2.82 (1.34, 5.91) | 0.0061 | 2.20 (0.99, 4.89) | 0.0536 |
| Tertile 3 (422–563) | 5.96 (3.01, 11.79) | 5.96 (2.84, 12.49) | 4.90 (2.01, 11.98) | 0.0005 | ||
| P for trend | 2.15 (1.54, 3.02) | 0.0005 | ||||
| Models were derived from logistic regression models. Non-adjusted model adjust for: None. Adjust I model adjust for: maternal age; BMI; gestational week. Adjust II model adjust for: maternal age; BMI; gestational week;RDW;creatinine;TG; TC;ESR; ALT. OR – odds ratio; CI – confidence interval; SD – standard deviation; SUA– serum uric acid. | ||||||