The Impact of Serum Uric Acid Levels on Hypertensive Disorders of Pregnancy in Advanced Maternal Age Women: A Retrospective Study from a Single Center in China

15 February 2024: Clinical Research

Li Luo ^12ADEFG* , Sulan Huang ^2ABCEF** , Zhijie Zhuang ^3BE* , Yeping Mo ^4BE* , Ning Guo ^2CE , Liangqing Ge ^12E*

DOI: 10.12659/MSM.942629

Med Sci Monit 2024; 30:e942629

Table 5 Association of HUA and HDP in the original and the weighted cohorts.

	Non-adjusted		Adjust I		Adjust II
	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value

SUA group
Normal SUA	1.0		1.0		1.0
High SUA	4.49 (2.90, 6.96)		4.89 (3.10, 7.71)		3.43 (2.01, 5.84)
SUA as continuous variable (mmol/L)	1.01 (1.01, 1.01)		1.01 (1.01, 1.01)		1.01 (1.01, 1.01)
SUA per SD increase	2.13 (1.80, 2.53)		2.27 (1.88, 2.73)		2.00 (1.60, 2.48)
Tertile of SUA
Tertile 1 (104–280)	1.0		1.0		1.0
Tertile 2 (281–349)	1.62 (1.09, 2.41)	0.0179	1.75 (1.13, 2.70)	0.0116	1.56 (0.99, 2.44)	0.0541
Tertile 3 (350–653)	5.16 (3.50, 7.61)		6.11 (3.99, 9.35)		4.36 (2.73, 6.97)
P for trend

SUA group
Normal SUA	1.0		1.0		1.0
High SUA	2.02 (1.65, 2.47)		2.80 (2.24, 3.52)		3.62 (2.81, 4.66)
SUA as continuous variable (mmol/L)	1.01 (1.01, 1.01)		1.01 (1.01, 1.01)		1.01 (1.01, 1.01)
SUA per SD increase	1.74 (1.57, 1.94)		2.11 (1.87, 2.39)		2.28 (1.99, 2.62)
Tertile of SUA
Tertile 1 (104–280)	1.0		1.0		1.0
Tertile 2 (281–349)	1.65 (1.14, 2.39)	0.0082	1.89 (1.26, 2.83)		1.84 (1.19, 2.82)	0.0056
Tertile 3 (350–653)	4.29 (3.15, 5.83)		7.15 (5.06, 10.11)		7.35 (5.04, 10.71)
P for trend
A: In the original cohort; B: in the weighted cohort. Models were derived from logistic regression models. Adjust I model adjust for: maternal age; BMI; gestational week. Adjust II model adjust for: maternal age; BMI; gestational week;RDW;creatinine;TG; TC;ESR; ALT. OR – odds ratio; CI – confidence interval; SD – standard deviation; SUA– serum uric acid.