15 February 2024 : Database Analysis
The Impact of Serum Uric Acid Levels on Hypertensive Disorders of Pregnancy in Advanced Maternal Age Women: A Retrospective Study from a Single Center in China
Li Luo12ADEFG, Sulan Huang2ABCEF*, Zhijie Zhuang3BE, Yeping Mo4BE, Ning Guo2CE, Liangqing Ge12EDOI: 10.12659/MSM.942629
Med Sci Monit 2024; 30:e942629
Table 5 Association of HUA and HDP in the original and the weighted cohorts.
| Non-adjusted | Adjust I | Adjust II | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| SUA group | ||||||
| Normal SUA | 1.0 | 1.0 | 1.0 | |||
| High SUA | 4.49 (2.90, 6.96) | <0.0001 | 4.89 (3.10, 7.71) | <0.0001 | 3.43 (2.01, 5.84) | <0.0001 |
| SUA as continuous variable (mmol/L) | 1.01 (1.01, 1.01) | <0.0001 | 1.01 (1.01, 1.01) | <0.0001 | 1.01 (1.01, 1.01) | <0.0001 |
| SUA per SD increase | 2.13 (1.80, 2.53) | <0.0001 | 2.27 (1.88, 2.73) | <0.0001 | 2.00 (1.60, 2.48) | <0.0001 |
| Tertile of SUA | ||||||
| Tertile 1 (104–280) | 1.0 | 1.0 | 1.0 | |||
| Tertile 2 (281–349) | 1.62 (1.09, 2.41) | 0.0179 | 1.75 (1.13, 2.70) | 0.0116 | 1.56 (0.99, 2.44) | 0.0541 |
| Tertile 3 (350–653) | 5.16 (3.50, 7.61) | <0.0001 | 6.11 (3.99, 9.35) | <0.0001 | 4.36 (2.73, 6.97) | <0.0001 |
| P for trend | <0.0001 | <0.0001 | <0.0001 | |||
| SUA group | ||||||
| Normal SUA | 1.0 | 1.0 | 1.0 | |||
| High SUA | 2.02 (1.65, 2.47) | <0.0001 | 2.80 (2.24, 3.52) | <0.0001 | 3.62 (2.81, 4.66) | <0.0001 |
| SUA as continuous variable (mmol/L) | 1.01 (1.01, 1.01) | <0.0001 | 1.01 (1.01, 1.01) | <0.0001 | 1.01 (1.01, 1.01) | <0.0001 |
| SUA per SD increase | 1.74 (1.57, 1.94) | <0.0001 | 2.11 (1.87, 2.39) | <0.0001 | 2.28 (1.99, 2.62) | <0.0001 |
| Tertile of SUA | ||||||
| Tertile 1 (104–280) | 1.0 | 1.0 | 1.0 | |||
| Tertile 2 (281–349) | 1.65 (1.14, 2.39) | 0.0082 | 1.89 (1.26, 2.83) | <0.0001 | 1.84 (1.19, 2.82) | 0.0056 |
| Tertile 3 (350–653) | 4.29 (3.15, 5.83) | <0.0001 | 7.15 (5.06, 10.11) | <0.0001 | 7.35 (5.04, 10.71) | <0.0001 |
| P for trend | <0.0001 | <0.0001 | <0.0001 | |||
| A: In the original cohort; B: in the weighted cohort. Models were derived from logistic regression models. Adjust I model adjust for: maternal age; BMI; gestational week. Adjust II model adjust for: maternal age; BMI; gestational week;RDW;creatinine;TG; TC;ESR; ALT. OR – odds ratio; CI – confidence interval; SD – standard deviation; SUA– serum uric acid. | ||||||