The Impact of Serum Uric Acid Levels on Hypertensive Disorders of Pregnancy in Advanced Maternal Age Women: A Retrospective Study from a Single Center in China

15 February 2024 : Database Analysis

Li Luo^12ADEFG, Sulan Huang^2ABCEF*, Zhijie Zhuang^3BE, Yeping Mo^4BE, Ning Guo^2CE, Liangqing Ge^12E

DOI: 10.12659/MSM.942629

Med Sci Monit 2024; 30:e942629

Background Material and Methods Results Discussion Conclusions References

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Table 6 Effect size of SUA on HDP in prespecified and exploratory subgroups.

Characteristic	No of participants	OR(95% CI)	P value	P value for interaction
GDM				0.1440
No	176	1.09 (1.06, 1.13)	<0.0001
Yes	76	1.04 (0.99, 1.10)	0.0977
Maternal age,years				0.9410
<40	200	1.08 (1.05, 1.11)	<0.0001
≥40	52	1.08 (1.01, 1.16)	0.0275
Platelets, 10/L				0.0485
<125	30	1.01 (0.93, 1.08)	0.08690
≥125	222	1.09 (1.06, 1.13)	<0.0001
RDW, %				0.9362
<14	110	1.08 (1.04, 1.12)	<0.0001
≥14	142	1.08 (1.04, 1.13)	<0.0001
BMI, kg/m				0.0326
<28	128	1.12 (1.07, 1.18)	<0.0001
≥28	124	1.05 (1.01, 1.09)	0.0087
SBP, mmHg				0.3300
<140	174	1.07 (1.03, 1.10)	0.0005
≥140	78	1.12 (1.02, 1.23)	0.0207
DBP, mmHg				0.6759
<90	186	1.08 (1.04, 1.12)	<0.0001
≥90	66	1.05 (0.97, 1.14)	0.2009
Gestational week, weeks				0.9383
<37	108	1.08 (1.04, 1.12)	<0.0001
≥37	144	1.08 (1.04, 1.13)	<0.0001
HR,beats/min				0.0832
<80	64	1.20 (1.10, 1.30)	<0.0001
≥80	376	1.09 (1.04, 1.09)	<0.0001
Anemia				0.3806
No	84	1.08 (1.02, 1.13)	0.0043
Yes	168	1.11 (1.07, 1.15)	<0.0001
Urine protein				0.2765
No	128	1.06 (1.03, 1.11)	0.0012
Yes	124	1.10 (1.05, 1.14)	<0.0001
Parity				0.3123
<1	54	1.01 (0.90,1.02)	0.0846
≥1	198	1.02 (1.01,1.04)	<0.0001
GDM – gestational diabetes; BMI – body mass index; RDW – red blood cell distribution width; SBP– systolic blood pressure; DBP – diastolic blood pressure; HR– heart rate.

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