10 March 2024>: Database Analysis
Potential of Gut Microbial Metabolites in Treating Osteoporosis and Obesity: A Network Pharmacology and Bioinformatics Approach
Md. Niaj Morshed 1ACEF* , Md. Rezaul Karim 12BE* , Reshmi Akter 1CDE , Safia Iqbal 1DF , Ramya Mathiyalagan 1CDF , Jong Chan Ahn 1BD , Deok Chun Yang 13CF , Joong Hyun Song 4CD , Se Chan Kang 1DFG* , Dong Uk Yang 15BFG*DOI: 10.12659/MSM.942899
Med Sci Monit 2024; 30:e942899
Table 1 Degree Centrality (DC), Betweenness Centrality (BC), and Closeness Centrality (CC) of (A) OP-related genes and (B) Obesity-related genes.
OP-related targets | Obesity-related targets | ||||||
---|---|---|---|---|---|---|---|
Genes | Degree | Betweenness | Closeness | Genes | Degree | Betweenness | Closeness |
HMOX1 | 64 | 861.001 | 1 | LEP | 63 | 275.484 | 1 |
LEP | 64 | 861.001 | 1 | IL18 | 63 | 275.484 | 1 |
MAPK3 | 35 | 110.504 | 0.688 | IL22 | 63 | 275.484 | 1 |
MAPK1 | 35 | 115.614 | 0.688 | GHRL | 63 | 275.484 | 1 |
AKT1 | 33 | 131.082 | 0.673 | G6PD | 63 | 275.484 | 1 |
MAPK14 | 31 | 89.494 | 0.659 | CHGA | 63 | 275.484 | 1 |
JUN | 30 | 75.113 | 0.653 | HMOX1 | 63 | 275.484 | 1 |
TP53 | 29 | 69.328 | 0.646 | MAPK3 | 37 | 50.895 | 0.707 |
PIK3CA | 28 | 78.459 | 0.64 | MAPK1 | 37 | 51.496 | 0.707 |
EGFR | 27 | 70.932 | 0.633 | TP53 | 35 | 48.729 | 0.692 |
NFKB1 | 25 | 60.085 | 0.621 | MAPK14 | 32 | 37.377 | 0.670 |
HDAC1 | 24 | 49.759 | 0.615 | MAPK8 | 31 | 34.744 | 0.663 |
MAPK8 | 24 | 51.501 | 0.615 | NFKB1 | 29 | 31.449 | 0.6494 |