10 March 2024 : Database Analysis
Potential of Gut Microbial Metabolites in Treating Osteoporosis and Obesity: A Network Pharmacology and Bioinformatics Approach
Md. Niaj Morshed
1ACEF, Md. Rezaul Karim12BE, Reshmi Akter1CDE, Safia Iqbal1DF, Ramya Mathiyalagan1CDF, Jong Chan Ahn1BD, Deok Chun Yang13CF, Joong Hyun Song4CD, Se Chan Kang1DFG*, Dong Uk Yang15BFG
DOI: 10.12659/MSM.942899
Med Sci Monit 2024; 30:e942899
Table 2 OP and Obesity target-related gut microbial metabolites.
| OP-related genes | Compounds | Obesity-related genes | Compound |
|---|---|---|---|
| HMOX1 | 10-Oxo-11-octadecenoic acid | G6PD | Urolithin A |
| LEP | Vancomycin | HMOX1 | 10-Oxo-11-octadecenoic acid |
| MAPK3 | Succinate | IL22 | Indole-3-carboxaldehyde |
| Butyrate | Tretinoin | ||
| Butyrate | LEP | Vancomycin | |
| Vancomycin | CHGA | Butyrate | |
| MAPK1 | Succinate | GHRL | Acetate |
| Butyrate | Butyrate | ||
| Butyrate | Propionate | ||
| Vancomycin | IL18 | Equol | |
| AKT1 | Indole | Indole | |
| Vancomycin | MAPK3 | Succinate | |
| MAPK14 | Vancomycin | Butyrate | |
| JUN | Butyrate | Butyrate | |
| Butyrate | Vancomycin | ||
| TP53 | Compound K | MAPK1 | Succinate |
| Urolithin A | Butyrate | ||
| PIK3CA | Indole | Butyrate | |
| EGFR | Indoxyl sulfate | Vancomycin | |
| p-Cresol sulfate | TP53 | Compound K | |
| Phenylacetylglutamine | Urolithin A | ||
| Indoxyl sulfate | MAPK14 | Vancomycin | |
| NFKB1 | 3-Indolepropionic acid | MAPK8 | Genipin |
| Butyrate | NFKB1 | 3-Indolepropionic acid | |
| HDAC1 | Butyrate | Butyrate | |
| MAPK8 | Genipin |