Potential of Gut Microbial Metabolites in Treating Osteoporosis and Obesity: A Network Pharmacology and Bioinformatics Approach

Md. Niaj Morshed; Md. Rezaul Karim; Reshmi Akter; Safia Iqbal; Ramya Mathiyalagan; Jong Chan Ahn; Deok Chun Yang; Joong Hyun Song; Se Chan Kang; Dong Uk Yang

doi:10.12659/MSM.942899

10 March 2024 : Database Analysis

Potential of Gut Microbial Metabolites in Treating Osteoporosis and Obesity: A Network Pharmacology and Bioinformatics Approach

Md. Niaj Morshed

^1ACEF, Md. Rezaul Karim^12BE, Reshmi Akter^1CDE, Safia Iqbal^1DF, Ramya Mathiyalagan^1CDF, Jong Chan Ahn^1BD, Deok Chun Yang^13CF, Joong Hyun Song^4CD, Se Chan Kang^1DFG*, Dong Uk Yang^15BFG

DOI: 10.12659/MSM.942899

Med Sci Monit 2024; 30:e942899

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Table 6 Disease-related micro-biome, substrates, metabolites, and targets.

Micro-biome	Substrate	Metabolites	CID	Target	Disease
Unknown	3,8,9-Trihydroxy-6H-benzo [c]chromen-6-one	Urolithin A	5488186	TP53	OP
	Ellagic acid	Urolithin A	5488186
	Ginsenoside Rb1	Compound K	9852086
	Tryptophan	Indole	798	AKT1
sp.	Geniposide	Genipin	442424	MAPK8
Unknown	3,8,9-Trihydroxy-6H-benzo [c]chromen-6-one	Urolithin A	5488186	TP53, G6PD	Obesity
	Ellagic acid
	Ginsenoside Rb1	Compound K	9852086
sp.	Geniposide	Genipin	442424	MAPK8
JS1	Isoflavone	Equol	91469	IL18
	Linolic acid	10-Oxo-11-octadecenoic acid	10308378	HMOX1

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Potential of Gut Microbial Metabolites in Treating Osteoporosis and Obesity: A Network Pharmacology and Bioinformatics Approach

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