Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

Xiaotong Liu; Ya Wen; Yanmei Lu

doi:10.12659/MSM.945211

22 October 2024 : Review article

Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

Xiaotong Liu^1E, Ya Wen^2E, Yanmei Lu

^1A*

DOI: 10.12659/MSM.945211

Med Sci Monit 2024; 30:e945211

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Introduction Pathophysiological Mechanism of Cardiac Cachexia Alterations in Hormone Levels Excessive Inflammatory Responses Unbalanced Protein Synthesis and Degradation Structure and Functions of MuRF1 Development of Related Inhibitors Targeting MuRF1 Discussion References

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Table 1 MuRF1-targeting inhibitors.

Reference	Molecular	Sample	Experimental group model	Target
Eddins et al, (2011) []¹⁰⁴	P013222	C2C12 cells	Dexamethasone (DEX) was used to induce muscle cell atrophy model	MuRF1 activity
Bowen et al, (2017) []¹⁰⁵	ID#709496	C2C12 cells, C57/BL6mice	A model of myocardial atrophy induced by monocrotaline (MCT) was established	MuRF1-titin
Adams et al, (2019) []¹⁰⁶	ID#709496	C57/BL6 female mice	Myocardial infarction was induced by surgical ligation of the left anterior descending coronary artery to induce heart failure	MuRF1-titin
Adams et al, (2020) []¹⁰⁹	MyoMed-946, MyoMed-205	C57BL/6N male mice	A model of cancer cachexia induced by melanoma cells	MuRF1 activity
Adams et al, (2022) []³²	MyoMed-205	Female obese ZSF1 rats	Obesity-induced HFpEF model	MuRF1 activity
Ribeiro et al, (2023) []¹¹²	MyoMed-205	Wistar rats	Unilateral diaphragm denervation model	MuRF1 activity

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Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

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